摘要
目的:探讨慢性精神分裂症患者伴发代谢综合征(MS)的危险因素、患病率及与血清脑源性神经营养因子(BDNF)水平的关系。方法:采用横断面研究方法,收集入组者一般人口学资料及临床资料,检测入组者血糖、血脂及血清BDNF水平。采用中华医学会糖尿病学分会(CDS)的标准诊断,将病程≥5年的慢性精神分裂症患者分为MS组及非MS组,分析慢性精神分裂症患者伴发MS的危险因素。结果:共有298例慢性精神分裂症患者入组,其中44例(14.7%)伴发MS纳入MS组;254例入非MS组。两组一般人口学资料比较差异无统计学意义(P>0.05)。MS组阳性与阴性症状量表(PANSS)中阴性症状因子分明显低于非MS组(P<0.05);血清BDNF水平明显高于非MS组(P<0.01)。二分类Logistic回归分析显示,血清BDNF水平增高是慢性精神分裂症患者伴发MS的危险因素(OR=1.658,P=0.005);阴性症状因子是伴发MS的保护性因素(OR=0.941,P=0.027)。结论:血清BDNF水平升高是慢性精神分裂症患者伴发MS的危险因素。
Objective:To explore the risk factors and prevalence of metabolic syndrome(MS)in patients with chronic schizophrenia and its relationship with serum brain-derived neurotrophic factor(BDNF).Method:A cross-sectional study was used to collect general demographic data and clinical data.Blood glucose,blood lipids and serum BDNF levels were detected.According to the standard diagnosis of Diabetes Branch of Chinese Medical Association(CDS),patients with chronic schizophrenia with a course of more than 5 years were divided into MS group and non-MS group.The risk factors of chronic schizophrenia complicated with MS were analyzed.Results:A total of 298 patients with chronic schizophrenia were enrolled in the group,including 44 patients(14.7%)with MS in the MS group and 254 patients in the non-MS group.There were no significant differences in general demographic data between the two groups(all P>0.05).The score of negative symptom of Positive and Negative Symptom Scale(PANSS)in the MS group was significantly lower than that in the non-MS group(P<0.05),and the serum BDNF level in the MS group was significantly higher than that in the non-MS group(P<0.01).Binomial Logistic regression analysis showed that the increase of serum BDNF level was a risk factor for MS in patients with chronic schizophrenia(OR=1.658,P=0.005),and PANSS-negative symptom factor was a protective factor for MS(OR=0.941,P=0.027).Conclusion:The increase of serum BDNF level is a risk factor for MS in patients with chronic schizophrenia.
作者
袁晓平
杨亚婷
张雨龙
李文正
姚献虎
夏磊
张凯
刘寰忠
YUAN Xiao-ping;YANG Ya-ting;ZHANG Yu-long;LI Wen-zheng;YAO Xian-hu;XIA Lei;ZHANG Kai;LIU Huan-zhong(Chaohu Hospital of Anhui Medical University,Hefei 238000,China)
出处
《临床精神医学杂志》
CAS
2022年第3期194-197,共4页
Journal of Clinical Psychiatry
基金
安徽省转化医学研究院科研基金项目(2017zhyx18)
安徽省重点研究和开发计划项目(1804h08020263)。
