摘要
目的:研究分析舒眠胶囊联合米氮平治疗抑郁症伴失眠患者的应用价值。方法:选择包头市第六医院2020年6月—2022年3月收治的90例抑郁症伴失眠患者作为本次研究对象,以随机数字表法分为对照组和观察组,每组45例。对照组患者接受米氮平治疗,观察组在对照组基础上加用舒眠胶囊治疗。对比两组临床治疗效果、睡眠质量、抑郁情况、生活质量、不良反应。结果:观察组临床疗效显著高于对照组,差异有统计学意义(P<0.05)。治疗后两组汉密尔顿抑郁量表(HAMD-17)和匹兹堡睡眠质量指数(PSQI)评分均降低,生活质量指数(QL-I)评分均升高,观察组HAMD-17和PSQI评分均低于对照组,QL-I评分高于对照组(P<0.05)。观察组副反应量表(TESS)评分和不良反应发生率均高于对照组,但两组比较,差异均无统计学意义(P>0.05)。结论:针对抑郁症伴失眠患者,应用舒眠胶囊联合米氮平的治疗方案的临床效果理想,不仅抑郁症状得到缓解,其睡眠质量也得到了有效提高,且用药安全性高。
Objective:To study the application value of Shumian Capsules combined with Mirtazapine in the treatment of patients with depressive disorder complicated with insomnia.Method:A total of 90 patients with depressive disorder complicated with insomnia admitted to Baotou No.6 Hospital from June 2020 to March 2022 were selected as the objects of this study,and were divided into control group and observation group according to random number table method,with 45 cases in each group.Patients in the control group was treated with Mirtazapine,observation group was treated with Shumian Capsules on the basis of control group.The clinical treatment effect,sleep quality,depression situation,quality of life and adverse reactions were compared between the two groups.Result:The clinical efficacy of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the scores of Hamilton depression scale(HAMD-17)and Pittsburgh sleep quality index(PSQI)decreased in both groups,the scores of quality of life index(QL-I)increased in both groups,and the scores of HAMD-17 and PSQI in the observation group were lower than those in the control group,the scores of QL-I was higher than that in the control group(P<0.05).Treatment emergent symptom scale(TESS)scores and incidence of adverse reactions in the observation group were higher than those in the control group,but there were no statistical significances between the two groups(P>0.05).Conclusion:For patients with with depressive disorder complicated insomnia,the clinical effect of Shumian Capsules combined with Mirtazapine is ideal,not only the symptoms of depression can be relieved,but also the sleep quality can be effectively improved,and the drug safety is high.
作者
王娟
杨毅然
WANG Juan;YANG Yiran(Baotou No.6 Hospital,Inner Mongolia,Baotou 014040,China;不详)
出处
《中国医学创新》
CAS
2023年第31期72-75,共4页
Medical Innovation of China
关键词
舒眠胶囊
米氮平
抑郁症
失眠
生活质量
Shumian Capsules
Mirtazapine
Depressive disorder
Insomnia
Quality of life
