摘要
目的研究麝香保心丸联合替罗非班用于治疗老年糖尿病合并急性冠脉综合征的疗效及对HCT、PAR、FIB水平影响。方法选取医院2015年2月—2016年2月期间收治的行PCI的老年糖尿病合并急性冠脉综合征患者102例,根据随机数字表法分为对照组和观察组各51例。对照组给予替罗非班,治疗组在对照组基础上口服麝香保心丸,对比两组患者治疗后的临床疗效、心功能指标水平、血清炎性因子水平、血液流变学指标、大动脉弹性、MACCE发生率和出血事件发生率。结果经过治疗后,治疗组治疗有效率显著高于对照组(P<0.05);两组患者在治疗前D-D、IL-6、CRP和TNF-α水平差异无统计学意义(P>0.05);两组患者治疗后D-D、IL-6、CRP和TNF-α水平显著降低(P<0.05);并且治疗组降低程度较大(P<0.05);两组患者在治疗前LVEDV、LVEF、LVEDD差异无统计学意义(P>0.05);两组患者治疗后LVEF、LVEDD水平显著升高,LVEDV水平显著降低(P<0.05);并且治疗组改善程度较大(P<0.05);两组患者在治疗前HCT、PAR、FIB水平差异无统计学意义(P>0.05);两组治疗后HCT、PAR、FIB水平显著降低(P<0.05);并且治疗组降低程度较大(P<0.05);治疗组治疗后CAVI和ABI水平显著改善(P<0.05);对照组治疗后CAVI和ABI水平差异无统计学意义(P>0.05);治疗组治疗7、30 d后MACCE发生率显著低于对照组(P<0.05)。两组治疗7、30 d后皮肤瘀点、牙龈出血和消化道出血等出血事件发生率差异无统计学意义(P>0.05)。结论采用麝香保心丸联合替罗非班用于治疗老年糖尿病合并急性冠脉综合征具有较好的治疗效果,能够改善患者心功能,降低血清炎性因子水平,安全性较高,值得在临床上推广应用。
Objective To study the efficacy of Shexiang Baoxin Pill combined with tirofiban in the treatment of acute coronary syndrome(ACS)in elderly patients with diabetes mellitus(DM)and its effect levelsof HCT,PAR and FIB.Methods A total of 102 cases of elderly diabetic patients with acute coronary syndrome who underwent PCI in our hospital from February 2015 to February 2016 were selected and divided into two groups with 51 cases in each according to the random number table method.Tirofiban was given in the control group,and Shexiang Baoxin Pillwas taken orally in the treatment group on the basis of the control group.The clinical efficacy,cardiac function index level,serum inflammatory factor level,hemorheology index,arterial elasticity,MACCE incidence and bleeding event incidence were compared between the two groups after treatment.Results After treatment,the effective rate of the treatment group was significantly higher than that of the control group(P<0.05).There was no significant difference in levels of D-D,IL-6,CRP or TNF-αbetween the two groups before treatment(P>0.05).Levels of D-D,IL-6,CRP or TNF-αwere significantly reduced after treatment in both groups(P<0.05).And the reductiondegree in the treatment group was greater(P<0.05).There was no statistically significant difference in LVEDV,LVEF or LVEDD between the two groups before treatment(P>0.05).After treatment,levels of LVEF and LVEDD were significantly increased and LVEDV levels were significantly decreased in the two groups(P<0.05).And the improvement degree of the treatment group was greater(P<0.05).There was no significant difference in levels of HCT,PAR or FIB between the two groups before treatment(P>0.05).Levels of HCT,PAR and FIB weresignificantly reduced after treatment in both groups(P<0.05).And the reduction degreein the treatment group was greater(P<0.05).Levels of CAVI and ABI were significantly improved in the treatment group(P<0.05).There was no significant difference in levels of CAVI or ABI between patients in the control group after treatm
作者
梁瑞景
梁瑞凯
LIANG Ruijing;LIANG Ruikai(Department of Geriatrics,The First Affiliated Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China;Endocrinology Department,Hebei Geriatric Hospital,Shijiazhuang 050000,Hebei,China)
出处
《中华中医药学刊》
CAS
北大核心
2020年第7期215-219,共5页
Chinese Archives of Traditional Chinese Medicine
基金
河北省青年科技项目(20160441)
河北省中医药管理局项目(2019102)。
