摘要
目的系统评价麝香保心丸治疗冠心病的临床疗效。方法对中国知网(Chinese National Knowledgey Ifrastructure,CNKI)、万方数据库(WanFang Data)、维普(Vip database)、中国生物医学文献数据库(China Biology Medicine disc,CBMdisc)、PubMed及Cochrane Library进行检索,选择其中包含麝香保心丸治疗冠心病的随机对照实验(randomized controlled trial,RCT),检索时限为数据库建库至2020年5月31日,结合纳入标准及排除标准对文献进行筛选,提取文献资料,进行方法学质量评价,以Cochrane系统评价手册对质量评价标准进行评价,以RevMan5.3软件进行Meta分析。结果最终纳入9篇文献,累计纳入冠心病患者3424例,组间基线资料比较差异无统计学意义,具有可比性;纳入研究的9篇文献中,2篇对hs-CRP水平进行报道,且经异质性检验,I_(2)=21%<50%,Q检验P=0.19>0.1,即文献间异质性低,应用固定效应模型进行Meta分析;Meta分析结果显示,RR=0.45,95%CI(0.33,0.49),经统计学显著性检验,Z=11.81,P<0.01;纳入研究的9篇文献中,5篇对心血管事件发生率进行报道,且经异质性检验,I_(2)=16%<50%,Q检验P=0.24>0.1,即文献间异质性低,应用固定效应模型进行Meta分析;Meta分析结果显示,RR=0.41,95%CI(0.35,0.47),经统计学显著性检验,Z=10.63,P<0.01;纳入研究的9篇文献中,2篇对死亡率进行报道,且经异质性检验,I_(2)=27%<50%,Q检验P=0.16>0.1,即说明文献间异质性低,应用固定效应模型进行Meta分析;Meta分析结果显示,RR=0.45,95%CI(0.37,0.45),经统计学显著性检验,Z=11.24,P<0.01;hs-CRP为中等质量证据,心血管事件发生率及死亡率则为低质量证据。结论麝香保心丸联合西医常规手段治疗冠心病的疗效显著优于仅应用西医常规治疗,且降低hs-CRP水平。
Objective To systematically evaluate the clinical efficacy of Shexiang Baoxin pills in the treatment of coronary heart disease.Methods Searched in the Chinese National Knowledgey Ifrastructure(CNKI),WanFang Data,Vip database,China Biology Medicine disc(CBMdisc),PubMed and Cochrane Library,and selected the randomized controlled trial(RCT)containing Shexiang Baoxin pills in the treatment of coronary heart disease,set the search time limit to the establishment of the database until May 31,2020,and screen the literature based on the inclusion and exclusion criteria.And extract the literature data,carry on the methodological quality evaluation to it,evaluate the quality evaluation standard with the Cochrane system evaluation manual,and carry out the Meta-analysis with the RevMan 5.3 software.Results A total of 9 articles were finally included in the study,and a total of 3424 patients with coronary heart disease were included.There was no statistically significant difference in the baseline data between the groups,and the baseline data between the groups was comparable;among the 9 papers included in the study,2 reported on hs-CRP levels,and after heterogeneity test,I_(2)=21%<50%,Q test P=0.19>0.1,that is,the heterogeneity between the literature is low,application Meta-analysis of fixed-effects model;Meta-analysis results showed that RR=0.45,95%CI(0.33,0.49),after statistical significance test,Z=11.81,P<0.01;5 of the 9 articles included in the study report on the incidence of cardiovascular events,and after heterogeneity test,I_(2)=16%<50%,Q test P=0.24>0.1,that is,the heterogeneity between documents is low,and the fixed effects model is used for Meta-analysis;the Meta-analysis results showed that RR=0.41,95%CI(0.35,0.47),after statistical significance test,Z=10.63,P<0.01;among the 9 articles included in the study,2 reported on the mortality rate,and after the heterogeneity test,I_(2)=27%<50%,Q test P=0.16>0.1,which means that the heterogeneity between documents is low,and the fixed-effects model is used for Meta-analys
作者
林杰忠
谢桂庭
刘锦光
LIN Jiezhong;XIE Guiting;LIU Jinguang(Department of Cardiology,Huizhou Central People's Hospital,Huizhou,Guangdong,516001,China)
出处
《当代医学》
2022年第2期119-122,共4页
Contemporary Medicine
