摘要
目的:探讨麦芽对精神分裂症患者药源性血清泌乳素升高及代谢综合征的临床治疗效果。方法:将120例住院精神分裂症患者分为利培酮组和奥氮平组,两组患者入组次日即开始接受麦芽水煎剂治疗。比较两组患者不同时间血清泌乳素(PRL)、空腹血糖(FBG)、甘油三酯(TG)、BMI指数的检测指标,阳性与阴性症状量表(PANSS)、临床总体印象量表疗效总评(CGI-GI)、治疗时出现的症状量表(TESS)的得分。结果:入组次日,入组2、4、6周后,两组患者相比较,PRL、FBG、TG、BMI的检测值及PANSS、CGI-GI、TESS量表得分差异均无统计学意义(P>0.05);在入组2、4、6周后,各组患者自身比较,PRL、FBG、TG、BMI的检测值及PANSS、CGI-GI、TESS量表得分均低于前1个时间段,且差异有统计学意义(P<0.05)。结论:麦芽能够显著降低由抗精神病药利培酮和奥氮平引起的血清泌乳素升高,对糖脂代谢、体脂量等指标也有明显的改善作用,同时还能减轻抗精神病药引起的其他副反应。
Objective:To investigate the clinical effect of malt on drug-induced serum prolactin elevation and metabolic syndrome in patients with schizophrenia.Method:A total of 120 hospitalized schizophrenic patients were randomly divided into Risperidone group and Olanzapine group,and the two groups began to receive malt decoction the next day after enrollment.The serum prolactin(PRL),fasting blood glucose(FBG),triglyceride(TG),BMI,positive and negative symptom scale(PANSS),total clinical impression scale(CGI-GI),and treatment symptom scale(TESS)were compared between the two groups.Result:On the second day after enrollment,at 2,4,and 6 weeks after enrollment,there were no statistically significant differences in PRL,FBG,TG,BMI,PANSS,CGI-GI,TESS scores between the two groups(P>0.05).After 2,4 and 6 weeks of inclusion,the test values of PRL,FBG,TG and BMI,as well as the scores of PANSS,CGI-GI and TESS scale were all lower than those in the previous period,and the differences were statistically significant(P<0.05).Conclusion:Malt can significantly reduce the increase of serum prolactin caused by the antipsychotics Risperidone and Olanzapine,improve the glucose and lipid metabolism,body fat and other indicators,and reduce the other side effects caused by antipsychotics.
作者
杜菊梅
阮俊
石晶
黄杨梅
杨寅
朱大凤
DU Jumei;RUAN Jun;SHI Jing;HUANG Yangmei;YANG Yin;ZHU Dafeng(Yichang Special Care Hospital,Yichang 443005,China;不详)
出处
《中外医学研究》
2020年第24期137-139,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
