摘要
丘脑中央正中核位于上行激活系统和下行易化通路的共同通道,与皮质和皮质下核团具有广泛的投射联系。近年来众多研究指出,丘脑中央正中核在睡眠、麻醉和觉醒中可能发挥重要的调控作用。文章旨在总结近年来相关实验研究结果,重点阐述丘脑中央正中核的投射关系和功能分类,详细综述丘脑中央正中核在睡眠、麻醉和觉醒中的调控作用和机制,简要介绍其在促进植物状态向清醒转变中的应用。最终提出丘脑中央正中核可能是维持清醒状态,并介导机体由清醒状态向睡眠和麻醉状态转换的关键核团。
The central medial thalamus is located in the common pathway of the ascending activation system and the descending facilitation pathway.It has extensive projective connections with the cortical and sub-cortical nuclei.More evidences indicated that the central medial thalamus may play an important regulatory role in sleep,anesthesia and awakening.By summarizing the relevant experimental results in recent years,this review introduced the projective relationship and functional classification of the central medial thalamus,highlighted the regulatory role and mechanism of the thalamic central median nucleus in sleep,anesthesia and awakening and discussed the application in promoting the transformation from vegetative state to wakefulness.We finally suggested that the central medial thalamus may be the key nucleus in maintaining the wakefulness and mediating the transition from wake state to sleep and anesthesia state.
作者
李沛
魏金龙
杨谦梓
Li Pei;Wei Jinlong;Yang Qianzi(Department of Basic Medicine,Air Force Medical University,Xi'an 710032,China;Department of Anesthesiology and Perioperative Medicine,the First Affiliated Hospital,Air Force Medical University,Xi'an 710032,China)
出处
《国际麻醉学与复苏杂志》
CAS
2019年第12期1183-1186,I0009,共5页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金(81671373)
陕西省国际科技合作与交流计划(2017KW-052)。
关键词
丘脑
丘脑中央正中核
麻醉
睡眠
觉醒
Thalamus
Central medial thalamus
Sleep
Anesthesia
Wakefulness
