摘要
随着对分子靶点研究的不断深入,临床逐渐明确全身麻醉(简称全麻)药物的作用机制和分子水平,但尚未弄清其所指意识消失的具体神经机制。通过在全麻意识消失中分析丘脑皮质睡眠觉醒环路及分子靶点的作用,可对意识消失的具体机制进行探讨。当前多数研究认为“睡眠—觉醒”环路可受到全麻药物的作用而造成意识消失,且该环路结构中“丘脑一皮质”环路最为重要,所以“丘脑一皮质”网状结构、丘脑活动抑制与全麻意识消失关系密切。通过对“丘脑一皮质”睡眠觉醒环路及全麻意识消失的神经机制进行深入研究,可为研发更为高效的全麻药物提供理论支持。
With the development of molecular target research,the mechanism and molecular level of general anesthesia drugs have been gradually clarified,but the specific neural mechanism of the loss of consciousness referred to in general anesthesia drugs has not been clarified.By analyzing the role of thalamic cortical sleep-wake loop and molecular target in the loss of consciousness during general anesthesia,the specific mechanism of loss of consciousness can be discussed.Most current studies believe that“sleep-wake”loop can be caused by the effect of general anesthesia drugs and the“thalamo-cortex”loop is the most important in this loop structure,so the“thalamo-cortex”network structure and thalamic activity inhibition are closely related to the disappearance of consciousness under general anesthesia.Through the in-depth study of thalamic-cortical sleep-wake circuit and the neural mechanism of consciousness loss in general anesthesia,it can provide theoretical support for the development of more efficient drugs for general anesthesia.
作者
卢剑
LU Jian(Boxing County People′s Hospital,Binzhou 256500,China)
出处
《世界睡眠医学杂志》
2022年第2期215-217,共3页
World Journal of Sleep Medicine
关键词
丘脑
皮质
睡眠觉醒
分子靶点
全身麻醉
意识消失
Thalamus
Cortex
Sleep awakening
Molecular target
General anesthesia
Unconsciousness
