摘要
背景随着分子靶点研究的深入，全身麻醉药分子水平的作用机制逐渐明确，但全身麻醉药引起意识消失的神经机制尚不清楚。目的总结分子靶点及丘脑皮质睡眠觉醒环路在全身麻醉引起意识消失中的作用，探讨全身麻醉药物引起意识消失的神经机制。内容目前很多研究表明全身麻醉药通过作用于睡眠．觉醒环路引起意识消失，其中丘脑一皮质环路是该环路的重要结构，全身麻醉引起的意识消失与抑制丘脑的活动及丘脑一皮质网状结构密切相关。趋向深入研究全身麻醉药引起意识消失的分子以及丘脑皮质睡眠觉醒环路的神经机制，有助于研发出更有效的全身麻醉药物。
Background The mechanisms of general anesthetics, an extremely diverse group of drugs, cause reversible loss of consciousness have been a long-standing mystery. Gradually, a relatively small numbers of important molecular targets have emerged, and bow these drugs act on these target molecules is becoming clear. However, despite all progresses that had been made, we still lack a clear and comprehensive insight into the specific neurophysiological mechanism of anesthetic induced loss of consciousness. Objective This review will focus on the most recent advances regarding molecular targets and thalamie-cortical sleep-wake circuitry in anesthetic-induced loss of consciousness. Content Different general anesthetics can have effects at various points in the sleep-wake circuitry.The thalamus is important for the sleep-wake circuit. Anesthetic effect on unconsciousness is relatively decrease of thalamic activity. Also changes in thalamic -cortical network interactions appear as important component of the neural correlate of unconsciousness. Trend The progress in molecular targets and thalamic -cortical sleep -wake circuitry in anesthetic induced loss of consciousness will be helpful to develop new and safe effective anesthetics.
作者
张盼盼
钟琦
陈婷
邹玉凤
曹玥
陈畅
张宗泽
Zhang Panpan;Zhong Qi;Chen Ting;Zou Yufeng;Cao Yue;Chen Chang;Zhang Zongze(Department of Anesthesiology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China)
出处
《国际麻醉学与复苏杂志》
CAS
2018年第8期794-798,共5页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金（81571291,81671060,81771160）
关键词
麻醉
全身
丘脑
大脑皮质
睡眠觉醒环路
分子靶点
意识消失
Anesthesia
general
Thalamus
Cerebral cortex
Sleep-wake circuitry
Molecular targets
Loss of consciousness
