摘要
目的:观察调肺运脾化痰祛湿法治疗小儿咳嗽变异性哮喘的临床疗效及其对可溶性细胞黏附分子1(sICAM-1)的影响。方法:选取100例符合咳嗽变异性哮喘诊断标准的患儿,随机数字表法分为对照组(50例)和观察组(50例)。对照组应用常规西药治疗,观察组采用调肺运脾化痰祛湿法进行治疗,比较两组治疗后的临床疗效及对PEF和sICAM-1改善情况。结果:对照组总有效率为88.0%,观察组总有效率98.0%,两组间比较,观察组明显优于对照组,且差异显著(P<0.05)。治疗后,两组患儿的PEF值较治疗前均显著升高,且差异具有统计学意义(P<0.05),观察组PEF值明显高于对照组,组间差异显著(P<0.05)。治疗后,两组患儿血浆sICAM-1水平均明显降低(P<0.05),观察组血浆sICAM-1水平明显低于对照组,组间差异显著(P<0.05)。结论:调肺运脾化痰祛湿法应用于小儿咳嗽变异性哮喘的治疗中,临床疗效良好,改善气道阻塞,降低血浆sICAM-1水平。
Objective:To observe the clinical effect of Regulating Lung,Strengthening Spleen and Removing phlegm and dampness method in the treatment of cough variant asthma(CVA)in children and its effect on soluble cell adhesion molecule 1(sICAM-1).Methods:A total of 100 children who met the diagnostic criteria of CVA were selected and divided into control group(50 cases)and observation group(50 cases).The control group was treated with routine Western medicine,and the observation group was treated with the method of Regulating Lung,Strengthening Spleen and Removing phlegm and dampness.The clinical effect,PEF value and the level of sICAM-1 were compared between the two groups.Results:The total effective rate was 88.0%in the control group,while 98.0%in the observation group.The comparison between the two groups showed that the curative effect of the observation group was better than that of the control group,and the difference was significant(P<0.05).After treatment,the PEF value of the two groups was significantly raised(P<0.05),the PEF value of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the levels of plasma sICAM-1 in the two groups were decreased significantly(P<0.05),the level of plasma sICAM-1 in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:The method of Regulating Lung,Strengthening Spleen and Removing phlegm and dampness in the treatment of CVA in children,that can improve the clinical efficacy,reduce airway obstruction and lower sICAM-1 level.
作者
桑杲
滕源
何小军
郭自强
杜建民
SANG Gao;TENG Yuan;HE Xiaojun;GUO Ziqiang;DU Jianmin(Tongde Hospital of Zhejiang Province,Hangzhou,Zhejiang 310012;The First Affiliated Hospital of Zhejiang University,Hangzhou,Zhejiang 310003;Chinese Medicine Hospital of Fenghua,Fenghua,Zhejiang 315502)
出处
《中国中医药科技》
CAS
2020年第1期9-12,共4页
Chinese Journal of Traditional Medical Science and Technology
基金
浙江省中医药科技计划项目(2018ZB084)
国中医药人教发[2017]24号
关键词
小儿咳嗽变异性哮喘
调肺运脾化痰祛湿法
麻菀咳宁汤
可溶性细胞黏附分子1
cough variant asthma in children
Regulating Lung
Strengthening Spleen and Removing phlegm and dampness method
Mawan Kening Decoction
sICAM-1
