摘要
上皮-间质转化(EMT)是一种复杂的转化过程,在癌细胞的侵袭过程中发挥重要作用。癌细胞形态变化伴随多种细胞改变过程,如细胞间黏附改变、细胞基质、降解、上皮标志物、间充质标志物改变等。黏蛋白(MUC)广泛分布于各种组织器官的上皮细胞中,在EMT过程中起重要作用。同时,MUC还可介导信号转导和细胞黏附、参与肿瘤的浸润、转移等。本文就EMT和MUC在肿瘤研究中的进展作一综述。
Epithelial-mesenchymal transition( EMT) is a complex transformation process and plays an important role in the invasion of cancer cells. The morphological transformation in cancer cells are accompanied by various cellular processes such as alterations in cell adhesion,cell matrix degradation,changes in epithelial markers and mesenchymal markers. Mucin( MUC) is widely distributed in epithelial cells of various tissues and organs and plays an important role in EMT. Meanwhile,MUC also can mediate signal transduction and cell adhesion,participate in tumor invasion and metastasis. This article reviewed the advances in research on EMT and MUC in tumors.
作者
谭雅芹
彭志红
TAN Yaqin;PENG Zhihong(Gastroenterology Research Center, Army Medical University, Chongqing (400038))
出处
《胃肠病学》
2019年第4期243-246,共4页
Chinese Journal of Gastroenterology
基金
国家自然科学基金(81572455)
国家重点研发计划数字诊断装备研发重点专项(2017YCFC0112300)
重庆市基础科学与前沿技术研究一般项目(cstc2014jcyjA10008)
关键词
上皮-间质转化
黏蛋白类
肿瘤
Epithelial-Mesenchymal Transition
Mucins
Neoplasms
