摘要
目的分析Snail、Stathmin的表达与前列腺癌患者的组织学分级、临床分期的相关性及对患者术后生存率的影响。方法选择本院2018年12月至2021年5月间收治的186例前列腺癌患者作为观察组, 选择同期100例前列腺增生患者作为对照组;对两组样品行Snail、Stathmin免疫组化测定;采用Spearman相关性检验分析Snail、Stathmin的表达与前列腺癌患者组织学分级、临床分期的相关性;绘制卡米尔生存曲线分析Snail、Stathmin表达情况与患者术后生存率的关系。结果观察组的Snail和Stathmin阳性表达情况明显高于对照组, 差异均有统计学意义(均P<0.05);不同组织学分期患者的Snail、Stathmin表达呈明显差异, 其中G3期Snail、Stathmin阳性表达最高, G1期最低, 差异均有统计学意义(均P<0.05);不同临床分期患者的Snail、Stathmin表达存在明显差异, 其中D期患者的Snail、Stathmin阳性表达最高, A期阳性表达最低, 差异均有统计学意义(均P<0.05);前列腺癌患者的临床分期、组织学分级与Snail、Stathmin表达呈明显正相关(均P<0.05);Snail阴性或弱阳性和Stathmin阴性或弱阳性患者的术后无进展生存期明显高于Snail阳性或强阳性和Stathmin阳性或强阳性患者, 差异均有统计学意义(均P<0.05)。结论前列腺癌的临床分期、组织学分级与Snail、Stathmin表达呈明显正相关, 且Snail、Stathmin高表达可明显降低患者的术后生存率。
Objective To analyze the correlation between the expression of Snail and Stathmin and the histological grade and clinical stage of patients with prostate cancer,and the impact on the survival rate of patients after surgery.Methods A total of 186 patients with prostate cancer admitted to our hospital from December 2018 to May 2021 were selected as the observation group,and 100 patients with prostate hyperplasia were selected as the control group.Snail and Stathmin immunohistochemical tests were performed on tissue samples of the subjects.Spearman correlation test was used to analyze the correlation between Snail and Stathmin expression and histological grade and clinical stage of prostate cancer patients.Camille survival curve was drawn to analyze the relationship between Snail and Stathmin expression and postoperative survival rate.Results The Snail and Stathmin positive expressions in the observation group were significantly higher than those in the control group,with statistical significance(all P<0.05).There were significant differences in Snail and Stathmin expression among patients with different histological stages,among which C3 stage had the highest Snail and Stathmin positive expression,and Gl stage had the lowest expression,with statistical significance(all P<0.05).There were significant differences in Snail and Stathmin expression in patients with different clinical stages,the highest Snail and Stathmin positive expression in patients with stage D and the lowest positive expression in patients with stage A,the differences were statistically significant(all P<0.05).The clinical stage and histological grade of prostate cancer were positively correlated with Snail and Stathmin expression(all P<0.05).The progression-free survival of Snail negative or weakly positive patients and Stathmin-negative or weakly positive patients was significantly higher than that of Snail positive or strongly positive patients and Stathmin-positive or strongly positive patients,and the differences were statistically significant
作者
黄启秀
高闫尧
杨帆
杜文婷
赵季田
姜啸烨
Huang Qixiu;Gao Yanyao;Yang Fan;Du Wenting;Zhao Jitian;Jiang Xiaoye(Department of Urology,the Second Affiliated Hospial of Air Force Miliary Medical University,Xi'an 710038,China)
出处
《国际泌尿系统杂志》
2023年第6期1015-1019,共5页
International Journal of Urology and Nephrology
