摘要
上皮细胞间质化(EMT)描述了一种从有极性的不能移动的上皮细胞转化为间质细胞的分子重塑和表型改变,在胚胎发育以及成人的损伤修复、组织再生、器官纤维化等方面发挥重要作用,是肿瘤侵袭、转移和肿瘤耐药发生中的一个重要步骤。现在已经发现多个分子通路、miRNAs和EMT有关,由于EMT与肿瘤转移、耐药有重要关系,所以了解EMT相关机制对于了解肿瘤的转移和耐药有重要意义。本文现对EMT相关通路和miRNAs作一综述。
The epithelial to mesenchymal transition（ EMT） describes the molecular reprogramming and phenotypic changes which are characterized by a transition from polarized immotile epithelial cells to motile mesenchymal cells. It is not only critical for appropriateembryonic development,wound healing,tissue regeneration,organ fibrosis,and cancer progression,but also an important process in tumor invasion,metastasis,and tumor drug- resistance. Several molecular pathways and miRNAs have been found are related to EMT. As EMT are bound up with tumor invasion,metastasis,and drug- resistant,it is significant to acquaint ourselves with the relative mechanisms of EMT. Now this paper summarizes the relative pathways and miRNAs of EMT.
出处
《现代肿瘤医学》
CAS
2016年第15期2484-2487,共4页
Journal of Modern Oncology
基金
国家自然科学基金项目(编号:81371891)
关键词
EMT
信号通路
MIRNAS
epithelial-msenchymal transition（EMT）
signal transduction
microRNAs
