摘要
肿瘤细胞对化疗药物耐药是肿瘤治疗的主要障碍,肿瘤干细胞(CSC)是造成肿瘤耐药的最根本原因,故肿瘤治疗的关键应以CSC为治疗靶点。CSC概念的提出为癌症靶向治疗的研究带来了新的思路,提供了选择性杀伤CSC的靶向分子疗法,即新的药物应有选择的杀伤CSC而不损伤正常的干细胞,克服肿瘤耐药、防止治疗后的复发与转移,达到真正的治愈肿瘤。
Drug resistance is the most important obstacle in the treatment of cancer. People can know more about the mechanisms of drug resistance by study of cancer stem cells, and then identify new therapeutic targets and to develope better anticancer strategies. If we regard cancer stem cells as the therapeutic targets we can selectively kill cancer stem cells without harming normal ones, so overcome the drug resistance and avoid cancer relapse or metastasis.
出处
《基础医学与临床》
CSCD
北大核心
2006年第6期662-667,共6页
Basic and Clinical Medicine
关键词
肿瘤干细胞
耐药
靶向治疗
cancer stem cells
drug resistance
target therapy
