摘要
转移是胃癌的主要死因.研究胃癌的转移机制,能为未来发展治疗胃癌的新手段提供必要的理论基础.上皮间质转化是上皮细胞转化成间充质样细胞并伴随明显基因和表型改变的一种多阶段过程,这种转化亦可在肿瘤细胞中发生,其会赋予肿瘤细胞侵袭和转移能力,使其更易形成远处转移灶,故上皮间质转化是肿瘤发生转移的重要机制之一.本文综述了近年来上皮间质转化的相关生物标志物,包括细胞表面蛋白(E-cadherin、N-cadherin)、细胞骨架蛋白(-catenin、Vimentin)、转录因子(Snail、Twist、ZEB1、ZEB2)等在胃癌中的研究进展.
In gastric cancer, metastases are the major cause of death. Understanding the mechanism by which tumor cells invade and metastasize is essential to develop novel treatments for gastric cancer （GC）. Epithelial-mesenchymal transition （EMT） is a multistage process in which epithelial cells develop into mesenchymal-like cells with a large number of distinct genetic and epigenetic alterations. EMT also occurs in cancer, which endows invasive and metastatic properties upon cancer cells that favor successful colonization of distal target organs. Here, we summarize studies of known EMT biomarkers in the context of GC progression. The biomarkers discussed include cell-surface proteins （E-cadherin and N-cadherin）, cytoskeletal proteins （β-catenin and Vimentin）, and transcription factors （Snail, Twist, ZEB1 and ZEB2）.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第30期3204-3210,共7页
World Chinese Journal of Digestology
基金
福建省2012年临床医学重点专科基金资助项目
No.闽卫科教[2012]149号
福建省财政厅专项基金资助项目
No.2012B013~~
关键词
上皮间质转化
生物标记
肿瘤转移
胃癌
Epithelial-mesenchymal transition
Biological markers
Neoplasm metastases
Stomach neoplasms
