摘要
目的评价除湿解毒汤联合马齿苋外敷治疗湿热蕴肤型急性湿疹的疗效。方法将符合入选标准的80例湿热蕴肤型急性湿疹患者采用随机数字表法分为2组,每组40例,对照组口服盐酸西替利嗪片与外涂氢化可的松软膏治疗,观察组在对照组基础上加用除湿解毒汤联合马齿苋外敷治疗。2组均治疗2周,随访3个月。采用湿疹面积及严重度指数评估皮损形态、皮损面积、瘙痒程度,采用ELISA法检测血清IL-4、TNF-α、IgE水平,采用流式细胞仪检测血清CD4^+、CD8^+水平并计算CD4+/CD8+值,观察复发情况,评价临床疗效。结果观察组总有效率为97.5%(39/40)、对照组为80.0%(32/40),2组比较差异有统计学意义(χ^2=6.135,P=0.013)。观察组治疗后皮损面积、皮损形态、瘙痒评分均低于对照组(t值分别为5.060、4.391、8.761,P值均<0.01)。与对照组治疗后比较,观察组血清IL-4[(0.15±0.06)ng/L比(0.31±0.08)ng/L,t=10.119]、TNF-α[(19.03±3.26)ng/L比(25.58±4.03)ng/L,t=7.992]及CD8+[(24.32±2.10)%比(28.03±2.51)%,t=7.476]水平均降低(P<0.01);CD4^+[(33.42±3.53)%比(27.38±3.06)%,t=8.177]水平及CD4^+/CD8^+[(1.37±0.28)比(0.97±0.19),t=7.170]值均升高(P<0.01)。结论除湿解毒汤联合马齿苋外敷可有效减轻湿热蕴肤型急性湿疹患者的炎症反应,提高机体免疫力。
Objective To explore the efficacy and adverse reaction of modified Chushi-Jiedu decoction combined with external application of purslane in the treatment of acute eczema with damp heat and skin retention. Methods A total of 80 patients with damp heat skin type acute eczema were collected in the department of Dermatology of our hospital from January to December of 2017, and the patients were randomly divided into two groups, each 40 cases. The control group was treated with Cetirizine Hydrochloride Tablets and hydrocortisone ointment, and the observation group was treated with modified Chushi-Jiedu decoction combined with external application of purslane. The effects and adverse reaction of two groups were compared after 2 weeks of treatment. Results The total effective rate of the observation group was 97.5%(39/40), and the control group was 80.0%(32/40), where the comparison difference between the two groups was statistically significant (χ^2=6.135, P=0.013). After treatment, the lesion area and lesion form and pruritus scores of the observation group were significantly lower than those of the control group (t value were 5.060, 4.391, 8.761, P<0.01);the levels of IL-4 (0.15 ± 0.06 ng/L vs. 0.31 ± 0.08 ng/L, t=10.119), TNF-α(19.03 ± 3.26 ng/L vs. 25.58 ± 4.03 ng/L, t=7.992) of the observation group were significantly lower than those of the control group (P<0.01). The levels of CD4^+(33.42%± 3.53 % vs. 27.38%± 3.06%, t=8.177), CD4^+/CD8^+(1.37 ± 0.28 vs. 0.97 ± 0.19, t=7.170) in observation group were significantly higher than the control group (P<0.01), and the levels of CD8^+(24.32%± 2.10% vs. 28.03%± 2.51%, t=7.476) was significantly lower than the control group (P<0.01). Conclusions The modificatied Chushi-Jiedu decoction combined with external application of purslane is safe and effective for the treatment of acute eczema with damp heat and skin type, and it can alleviate the inflammatory reaction and improve the immunity of the body.
作者
张玲
林素财
郑永平
Zhang Ling;Lin Sucai;Zheng Yongping(Department of Dermatology,Zhongshan Hospital of Traditional Chinese Medicine,Zhongshan 528400,China)
出处
《国际中医中药杂志》
2019年第4期361-364,共4页
International Journal of Traditional Chinese Medicine
基金
广东省中医药局科研项目(20171280)
中山市社会公益科技研究专项资金项目(2017B1010).
关键词
湿疹
敷贴疗法
除湿解毒汤
马齿苋
湿热蕴肤型
辨证分型
免疫调节
Eczema
Plastering therapy
Chushi-Jiedu decoction
Portulacae herba
Damp heat accumulation skin type
Syndrome differentiation classification
Immunomodulation
