摘要
目的分析阿司匹林联合硫酸氢氯吡格雷治疗脑梗死的有效性和安全性。方法 72例脑梗死患者,随机分为对照组与实验组,每组36例。两组患者均给予常规治疗,在此基础上,对照组加用阿司匹林,实验组在对照组基础上联用硫酸氢氯吡格雷治疗。比较两组临床疗效与不良反应情况。结果治疗后实验组患者的神经功能缺损评分明显优于对照组,差异有统计学意义(P<0.05)。实验组患者的治疗总有效率为91.7%,高于对照组的72.2%,差异有统计学意义(P<0.05)。实验组不良反应发生率为5.6%,低于对照组的22.2%,差异有统计学意义(P<0.05)。结论阿司匹林联合硫酸氢氯吡格雷治疗脑梗死效果满意,安全性较高,可有效改善患者神经功能缺损情况,值得临床予以推广和应用。
Objective To analyze effectiveness and safety by aspirin combined with clopidogrel hydrogensulfate in the treatment of cerebral infarction.Methods A total of72patients with cerebral infarction wererandomly divided into control group and experimental group,with36cases in each group.Both groups receivedconventional therapy,and the control group also received aspirin for treatment.The experimental group receivedadditional clopidogrel hydrogen sulfate to aspirin for treatment.Evaluation was made on clinical effects andadverse reactions condition in the two groups.Results After treatment,the experimental group had obviouslybetter nerve function defect score than the control group,and the difference had statistical significance(P<0.05).The experimental group had higher total effective rate as91.7%than72.2%in the control group,and thedifference had statistical significance(P<0.05).The experimental group had lower incidence of adverse reactionsas5.6%than22.2%in the control group,and the difference had statistical significance(P<0.05).ConclusionCombination of aspirin and clopidogrel hydrogen sulfate shows satisfactory effect in treating cerebral infarction,along with high safety.This method can effectively improve nerve function defect condition in patients,and it isworth clinical promotion and application.
作者
陈奋伟
CHEN Fen-wei(Department of Cranial Brain, Haifeng County Pengpai Memorial Hospital,Shanwei 516400, China)
出处
《中国现代药物应用》
2017年第10期13-15,共3页
Chinese Journal of Modern Drug Application
关键词
脑梗死
阿司匹林
硫酸氢氯吡格雷
疗效
安全性
Cerebral infarction
Aspirin
Clopidogrel hydrogen sulfate
Curative effect
Safet
