摘要
目的分析阿司匹林联合硫酸氢氯吡格雷对脑梗死的临床治疗效果。方法84例脑梗死患者,随机分为研究组及对照组,各42例。对照组单纯行阿司匹林治疗,研究组行阿司匹林联合硫酸氢氯吡格雷治疗。比较两组患者的临床疗效、治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、不良反应发生情况。结果研究组总有效率为97.62%,高于对照组的78.57%,差异具有统计学意义(P<0.05)。治疗前,两组患者的NIHSS评分比较,差异无统计学意义(P>0.05);治疗后,两组患者的NIHSS评分均较本组治疗前降低,且研究组NIHSS评分(9.23±1.29)分低于对照组的(15.32±2.56)分,差异均具有统计学意义(P<0.05)。研究组不良反应发生率为7.14%,对照组不良反应发生率为2.38%,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论脑梗死患者采用阿司匹林联合硫酸氢氯吡格雷治疗可改善疾病预后与神经缺损状况。
Objective To analyze the clinical effect of aspirin combined with clopidogrel hydrogen sulfate in the treatment of cerebral infarction.Methods A total of 84 patients with cerebral infarction were randomly divided into research group and control group,with 42 cases in each group.The control group was treated with aspirin,and the research group was treated with aspirin combined with clopidogrel hydrogen sulfate.Comparison were made on clinical efficacy,National Institute of Health stroke scale(NIHSS)score before and after treatment and occurrence of adverse reactions between the two groups.Results The research group had higher total effective rate as 97.62%than 78.57%in the control group,and the difference was statistically significant(P<0.05).Before treatment,both groups had no statistically significant difference in NIHSS score(P>0.05).After treatment,both groups had lower NIHSS score than that before treatment,and the research group had lower NIHSS score as(9.23±1.29)points than(15.32±2.56)points in the control group.Their difference was statistically significant(P<0.05).The research group had incidence of adverse reactions as 7.14%,which was 2.38%in the control group.Both groups had no statistically significant difference in incidence of adverse reactions(P>0.05).Conclusion Combination of aspirin and clopidogrel hydrogen sulfate can improve disease prognosis and neurological deficit of patients with cerebral infarction.
作者
翟青玲
ZHAI Qing-ling(Department of Internal Medicine Neurology,Guangdong Integrated Traditional Chinese and Western Medicine Hospital,Foshan 528200,China)
出处
《中国实用医药》
2019年第20期23-25,共3页
China Practical Medicine
关键词
脑梗死
阿司匹林
硫酸氢氯吡格雷
神经功能
临床疗效
不良反应
Cerebral infarction
Aspirin clopidogrel hydrogen sulfate
Neurological function
Clinical efficacy
Adverse reactions
