摘要
JAK/STAT是一条重要的信号通路,介导多种细胞因子和生长因子的细胞内信号转导和基因转录过程。本文综述了JAK/STAT通路的组成、信号传导通路,并初步探讨JAK/STAT信号通路在心肌细胞、神经细胞、肝细胞、其他细胞凋亡中的作用机制及中药与JAK/STAT信号通路、细胞凋亡关系的相关研究。
(Janus kinase) / (Signal transducer and activators of transcription) is an important signal pathway that mediated a variety of intracellular signal transduction and gene transcription process of cytokines and growth factors. In this paper, the composition of JAK/STAT pathway and signaling pathways were summarzied; the action mechanism of JAK/STAT signaling pathways in myocardial cells,nerve cells, liver cells and other apoptosis cells were discussed; the relationship among the cell apoptosis, the function of JAK/STAT signaling pathway and TCM medicine was researched.
出处
《中医临床研究》
2016年第26期142-145,共4页
Clinical Journal Of Chinese Medicine
基金
基于JAK/STAT信号途径调控的益肾化瘀方干预肾间质纤维化机制,编号为81373612
关键词
JAK/STAT
细胞凋亡
中药干预
Janus kinase / Signal transducer and activators of transcription
Cell apoptosis
Intervention of TCM medicine
