摘要
缺血—再灌注(I/R)是指组织和器官在缺血后再次得到血液的过程,而在此过程中引起组织损伤加重的现象则称为I/R损伤。I/R损伤已经成为许多疾病中较严重的致死因素,其中最为棘手的是脑I/R损伤。大量研究表明导致脑I/R损伤的机制很多,比如炎症反应、细胞凋亡和氧化应激等。本文拟从信号通路对脑I/R损伤的保护性和损伤性作用机制入手,系统阐述导致脑I/R损伤的信号通路,从而更加深入地研究其病理生理机制,以便为临床治疗和针对性药物的研发提供参考。
Ischemia-reperfusion(I/R)refers to the process in which many tissues and organs get blood again after ischemia,and the phenomenon of tissue injured aggravating in this process is called ischemia-reperfusion(I/R)injury.I/R injury has become a serious fatal factor in many diseases,among which cerebral I/R injury is the most difficult.Many studies have shown that there are many mechanisms leading to cerebral I/R injury,such as inflammatory reaction,cell apoptosis and oxidative stress.In this paper,the signal pathway leading to cerebral I/R injury is systematically expounded from the protective and injurious mechanism of signal pathway on cerebral I/R injury,and its pathophysiological mechanism is further studied from the signal pathway,so as to provide reference for clinical treatment and targeted drug research and development.
作者
李澜芯
何甜
石清明
胡谍
李丹凤
肖莉
LI Lan-xin;HE Tian;SHI Qing-ming;HU Die;LI Dan-feng;XIAO Li(Chengdu Medical College,Chengdu Sichuan 610500,China;Disease Control and Prevention, Western Theater Command Center,Lanzhou Gansu 730020,China;Department of Human Anatomy and Embryology,Chengdu Medical College/Key Laboratory of Development and Regeneration,Chengdu Sichuan 610500,China)
出处
《局解手术学杂志》
2021年第4期359-362,共4页
Journal of Regional Anatomy and Operative Surgery
基金
四川省大学生创新实验项目(S201913705054,201713705076)
四川省教育厅项目(18ZB0179)
发育与再生四川省重点实验室开放基金项目(SYS16-010)。
关键词
缺血—再灌注
脑缺血—再灌注损伤
信号通路
作用机制
ischemia-reperfusion
cerebral ischemia-reperfusion injury
signal pathway
mechanism of action
