摘要
实验研究了在 5 14 nm波长激发下人体食道和乳腺组织 ,包括正常组织和癌变组织的时间分辨光谱。由时间分辨光谱拟合求得的特征峰荧光寿命结果表明 :食道正常组织和鳞癌组织的荧光寿命分别为 2 .0 9ns和 1.71ns,乳腺正常组织和腺癌组织的荧光寿命分别为 2 .0 5 ns和 1.4 3ns。正常组织的荧光寿命都大于癌变组织的荧光寿命 ,它们之间存在明显差异 ,这一方法将有助于结合稳态荧光光谱应用于早期癌变组织的精确诊断。
Time resolved spectroscopies for human esophageal and breast tissues in vitro have been measured under pulse generation at the wavelength of 514 nm.Lifetime of normal and squamous carcinoma human esophageal tissue have been respectively determined by time resolved detection of laser induced fluorescence rather than the traditional time integrated monitoring technique as 2.09 ns and 1.71 ns,while 2.05 ns and 1.43 ns for the human normal and adencarcinoma breast tissue,respectively.Experimental results show that sufficient difference is obtained between the lifetime of normal and carcinoma tissues,and the lifetime of normal tissues is slower than that of carcinoma tissues.Implications of time resolved spectroscopy for spectroscopic guidance in tissue diagnosis are indicated.
出处
《光电子．激光》
EI
CAS
CSCD
北大核心
2002年第10期1071-1073,共3页
Journal of Optoelectronics·Laser
基金
国家自然科学基金资助项目 (60 1780 2 2 )
福建省教育厅重大项目资助项目 (JA0 10 14 )
关键词
人体食道
乳腺组织
时间分辨光谱
自体荧光
荧光寿命
组织诊断
Time resolved spectroscopy
Fluorescence lifetime
Esophageal tissue
Breast tissue
Tissue diagnosis
