摘要
目的探讨微生态制剂对小儿急性感染性腹泻患者血清炎性因子、肠黏膜屏障功能、肠道菌群的影响。方法选择我院2017年6月—2017年10月收治的60例急性感染性腹泻患儿,随机分为2组,观察组30例采用微生态制剂(头孢他啶与双歧杆菌三联活菌)治疗,对照组30例采用头孢他啶治疗。比较2组临床症状消失时间、肠黏膜屏障功能、血清炎症因子水平及肠道菌群变化情况。结果与对照组相比,观察组脱水、腹泻及腹痛等症状消失时间较短,差异具有统计学意义(P<0.05);治疗后,观察组TNF-α、内毒素、IL-6、D-乳酸及DAO水平更低,乳酸菌、双歧杆菌水平更高,差异均有统计学意义(P<0.05)。结论微生态制剂治疗小儿急性感染性腹泻可有效缩短临床症状消失时间,促进肠道菌群恢复正常,减轻炎症反应,提高肠黏膜屏障功能。
Objective To investigate the effect of microecologics on serum inflammatory factors, intestinal mucosal barrier function, intestinal flora in children with acute infective diarrhea. Methods 60 children with acute infective diarrhea from June 2017 to October 2017 were randomly divided into two groups, 30 cases in each group. Observation group was given microecologics （ceftazidime and bifid triple viable 0, while control group was treated with ceftazidime. The disappearance time of clinical symptoms, intestinal mucosal barrier function, serum inflammatory factors and changes of intestinal flora were compared between the two groups. Results Compared with control group, the disappearance time of dehydration, diarrhea and abdominal pain in observation group were shorter （P〈0.05）.After treatment,compared with control group, the levels of TNF- a , endotoxin, I L-6,D-lactate and DAO in observation group were lower, while the levels of lactic acid bacteria and bifidobacterium were higher （P〈0.05 ）.Conclusion Microecologics in treatment of children with acute infective diarrhea can effectively shorten disappearance time of clinical symptoms, promote recovery of intestinal flora, reduce inflammatory response and increase intestinal mucosal barrier function.
作者
欧阳美文
周树根
王磊鑫
Ouyang Meiwen;Zhou Shugen;Wang Leixin.(The family planning service center of maternal and children health care in Ji＇an, Ji＇an, Jiangxi 34320)
出处
《基层医学论坛》
2018年第14期1873-1875,共3页
The Medical Forum
基金
吉安市科技计划任务
关键词
小儿急性感染性腹泻
微生态制剂
血清炎性因子
肠黏膜屏障功能
肠道菌群
Children with acute infective diarrhea Microecologics Serum inflammatory factors Intestinal mucosal barrier function Intestinal flora
