摘要
目的探讨微生态制剂对小儿急性感染性腹泻患者肠黏膜屏障功能肠道菌群的影响。方法选取该院2015年1月—2017年1月收治的90例急性感染性腹泻患儿为研究对象,所有患儿均经临床检查确诊,根据不同治疗方法将本组患儿分为两组,观察组45例患儿给予微生态制剂治疗,对照组45例患儿给予头孢他啶治疗,对比两组患儿的临床症状消失时间和治疗前后肠道菌群水平和肠黏膜屏障功能。结果观察组患儿腹痛、腹泻、脱水症状消失时间分别为(43.98±10.46)h、(34.35±7.76)h、(19.40±3.03)h,对照组分别为(51.38±10.43)h、(42.47±9.14)h、(22.43±4.30)h,观察组明显快于对照组,差异有统计学意义(t=3.360 6、4.543 0、3.864 0,P<0.05)。治疗后观察组患儿双岐杆菌、乳酸菌、DAO、D-乳酸水平分别为(10.85±1.14)logCFU/g、(10.09±0.63)logCFU/g、(3.95±1.25)U/L、(4.54±1.32)mg/L;对照组组患儿分别为(9.61±1.12)logCFU/g、(9.55±0.87)logCFU/g、(7.31±2.20)U/L、(7.41±1.23)mg/L。治疗后两组患儿均有所改善,但观察组患儿改善更为明显,差异有统计学意义(t=5.205 0、3.3724、8.907 8、10.670 7,P<0.05)。结论小儿急性感染性腹泻患者给予微生态制剂治疗可有效减轻临床症状,降低炎症因子水平,改善肠道菌群,提高肠黏膜屏障功能,值得临推广。
Objective To investigate the effects of microecological preparations on intestinal mucosal barrier function in intestinal tract in children with acute infectious diarrhea. Methods A total of 90 children with acute infectious diarrhea admitted to the hospital from January 2015 to Januat7 2017 were enrolled in the study. All children were diagnosed by clinical examination. According to different treatment methods, the children in this group were divided into two groups. In the observation group, 45 patients were treated with microecological preparations, and 45 patients in the control group were treated with ceftazidime. The clinical symptoms disappeared and the intestinal flora level and intestinal mu- cosal barrier function before and after treatment were compared between the two groups. Results The disappearance time of abdominal pain, diarrhea and dehydration in the observation group were （43.98±10.46）h, （34.35 ±7.7）h and （19.40±3.03）h, respectively. The control group was （51.38±10.43）h, （42.47±9.14）h and （22.43±4.30）h, respectively. The group was significantly faster than the control group, and the difference was statistically significant （t=3.360 6, 4.543 0, 3.864 0, P〈0.05）. After treatment, the levels of Bifidobacterium, lactic acid bacteria, DAO and D-lactic acid in the ob- servation group were （10.85 ± 1.14）logCFU/g, （10.09±0.63）logCFU/g, （3.95 ± 1.25）U/L, （4.54± 1.32）mg/L;the control group had （9.61±l.12）logCFU/g, （9.55±0.87）logCFU/g, （7.31±2.20）U/L, and （7.41±l.23）mg/L, respectively. Both groups im- proved after treatment, but the improvement in the observation group was more obvious, the difference was statistically significant （t=5.205 0, 3.372 4, 8.907 8, 10.677 0, P〈0.05）. Conclusion The treatment of micro-ecological preparations in children with acute infectious diarrhea can effectively alleviate clinical symptoms, reduce the level of inflammatory factors, improve intestinal flora and improve intestinal mucosal barrie
作者
王蓬伟
国平
郭玉秀
WANG Peng-wei;GUO Ping;Guo Yu-xiu(Department of Pediatrics,Weifang Maternal and Child Health Hospital,Weifang,Shandong Province,261042 China)
出处
《系统医学》
2018年第20期94-95,100,共3页
Systems Medicine
关键词
微生态制剂
小儿
急性感染性腹泻
血清炎性因子
肠黏膜
屏障功能
肠道菌群
Microecological preparation
Pediatric
Acute infectious diarrhea
Serum inflammatory factor
Intestinalmucosa
Barrier function
Intestinal flora
