摘要
目的探讨核因子-E2相关因子2（Nrf2）／血红素氧化酶（HO）-1通路在慢性阻塞性肺疾病（COPD）患者营养不良中的作用及其与肿瘤坏死因子（TNF）-α的关系。方法将60例稳定期男性COPD患者分为COPDI组（COPD伴营养不良患者）30例，COPDⅡ组（营养正常的COPD患者）30例，同期健康男性体检者30例为对照组，测量3组研究对象的白蛋白（A1b）、肱三头肌皮褶厚度（TSF）、上臂肌围（AMC）、BMI及实际体重占理想体重百分比（IBW％）等营养指标，采用酶联免疫吸附试验测定血浆Nrf2、HO-1及TNF-α浓度。结果COPDI组的TSF、A1b、AMC、BMI、IBW％均低于COPDⅡ组及对照组，COPDⅡ组的TSF、A1b、AMC明显低于对照组，差异均有统计学意义（P〈0．05）；但COPDⅡ组的BMI、IBW％和对照组比较，差异无统计学意义（P〉0．05）。COPDI组血浆Nrf2、HO-1浓度低于COPDⅡ组及对照组，TNF—α浓度高于COPDⅡ组及对照组，COPDⅡ组血浆Nrf2、HO-1浓度低于对照组，TNF-α浓度高于对照组，差异均有统计学意义（P〈0．05）。COPD姐、嘲患者血浆Nr12与HO-1均呈正相关（r=0．823，P〈0．001；r=0．513，P=0．042）；COPDI组、Ⅱ组患者血浆Nrf2、HO-1与TNF-α均无相关性（P〉0．05）。结论Nrf2／HO-1通路可能在一定程度上延缓男性COPD患者营养不良的进展，但与TNF-α无明显相关关系。
Objective To explore the role of nuclear factor-E2 related factor 2 （Nrf2）/Heine oxygenase-1 （HO-1） pathway in malnutrition of patients with chronic obstructive pulmonary disease （COPD） and its relationship with tumor necrosis factor（TNF）-cc Methods Sixty male patients with stable COPD were divided into COPD I group（ patients with malnutrition,30 cases） and COPD Ⅱ group（ patients with normal nutrition,30 cases）. Thirty cases of healthy male subjects during the same period were selected as control group. Albumin （ Alb ）, triceps skin-fold thickness （ TSF ） , arm muscle circumference （ AMC ）, BMI and percentage of ideal body mass（ IBW% ） were measured in all subjects. Concentrations of Nrf2, HO-1 and TNF-α in plasma of all subjects were detected by enzyme-linked immunosorbent assay. Results TSF,Alb,AMC,BMI and IBW% in COPD I group were significantly lower than those in COPDⅡand control group. TSF,Alb and AMC in COPDⅡ group were significantly lower than those in control group （P 〈 0. 05 ） , but BMI and IBW% were not significantly different between COPD Ⅱ group and control group（ P 〉 0. 05 ）. Concentrations of Nrf2 and HO-1 in plasma in COPD I group were lower and TNF-α was higher than those in COPD Ⅱ group and control group（ P 〈 0.05 ）. Concentrations of Nrf2 and HO-1 in plasma in COPD II group were lower and TNF-α was higher than those in control group（ P 〈 0. 05 ）. Nrf2 in plasma was positively correlated with HO-1 in COPD Ⅰ and COPD Ⅱgroup （ r = 0. 823, P 〈 0. 001 ; r = 0. 513, P = 0. 042）. There was no significant correlation between Nrf2, HO-1 and TNF-α in COPD Ⅰ and COPD Ⅱ group （ P 〉 0. 05 ）. Conclusion. Nrf2/HO-1 pathway may delay the progression of malnutrition in male COPD patients to some extent, but it has no significant correlation with TNF-α.
出处
《临床内科杂志》
CAS
2017年第9期628-630,共3页
Journal of Clinical Internal Medicine
