摘要
抑郁症是严重危害个体及社会的公共卫生问题,而现有主流抗抑郁西药有起效缓慢的缺点。近年来系列研究发现,在多种抑郁症模型及临床研究中,解郁名方越鞠丸显示出类似于快速抗抑郁原型药氯胺酮的优势特点,其快速持久增强神经可塑性机制,个体化差异机制,以及栀子作为快速抗抑郁君方的实验证据与机制等也被揭示出来。广泛深入开展相关研究将为抑郁症的防治提供科学可靠的中医药方案做出贡献。
Major depression is a public health problem that seriously harms individuals and the society. But one of the major shortcomings of mainstream antidepressant is the delayed onset. Recent series of studies demonstrated that, from a variety of animal models and clinical studies, classic stagnation-removing formula Yue-Ju （YJ） pill has the advantage in rapid antidepressant efficacy, which is similar to the prototype drug ketamine. It has the mechanism of rapid and sustained enhancement of neural plasticity and individual difference in response to YJ pill. The evidence of Gardenia jasminoides （Zhi-Zi） as the monarch component of YJ pill＇s rapid antidepressant action has also been revealed. The further in-depth research on rapid antidepressant traditional Chinese medicine （TCM） is important for providing the scientific and reliable TCM strategies to treat depression.
出处
《世界科学技术-中医药现代化》
CSCD
2017年第8期1283-1288,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委面上项目(81403041):基于PACAP-CREB信号通路的越鞠丸快速抗抑郁机制研究
负责人:陈刚
江苏省自然科学基金委资助项目(BK20151568):PACAP介导越鞠丸快速抗抑郁作用研究
负责人:陈刚
江苏省双创团队项目:新型治疗抑郁症中药研发
负责人:陈刚
关键词
越鞠丸
栀子
快速抗抑郁
动物模型
神经与个体化反应机制
Yue-Ju pill, Gardenia jasminoides, rapid antidepressant, animal model, neural and individualized drug response mechanism
