摘要
目的:观察越鞠丸对慢性轻度不可预见性的应激抑郁(CUMS)小鼠模型的影响,揭示该方对抑郁症的药效及作用机理。方法:实验分组:健康昆明种小鼠随机分为4组,即空白对照组(简称空白组)、模型组、阳性药物对照组(简称对照组)、越鞠丸组,每组12只。越鞠丸组小鼠给予该方水煎液灌胃;对照组予阿米替林等容积混悬液灌胃;空白组、模型组均予等容积生理盐水灌胃,连续18天。记录5分钟小鼠自主活动次数,并记录5分钟内小鼠的激惹次数及检测5-HT的含量及血浆皮质醇浓度。结果:越鞠丸组小鼠行为学指标明显改善,疗效与对照组比较无显著性差异(P>0.05)。结论:升高抑郁症模型小鼠脑组织中的5-HT含量,降低血浆皮质醇含量是越鞠丸作用的部分机理。
Objective： Observe the effect of Yueju pill to chronic unpredictable mild stress（CUMS） mouse, to reveal the drug action and the mechanism of the medicine, Methods： Divide into groups： healthy kunming mouse were divide into 4 groups, that is blank control group（to abbreviate blank group）, model, masculine drug group（to abbreviate control group） and Yueju pill group, 12 mouse per group. Yueju pill group were lavaged with the decoct of it, control group were labaged with amitriptyline, blank and model group were both lavaged with normal saline, continue 18 days. Record the autonomic activities frequency, and record irritation frequency in 5 minutes, and detect the content of 5-HT and plasma cortisol. Results： the index of ethology of mouse was improved treated with Yueju pill, contrast to the control group, the curative effect has no significant difference （P〈0.05）. Conclusions： increasing the level of 5-HT of brain tissue in depressive disorder mouse and decreasing the content of plasma cortisol may be the mechanism of Yueju pill.
出处
《江西中医学院学报》
2007年第2期64-67,共4页
Journal of Jiangxi College of Traditional Chinese Medicine
关键词
郁证
越鞠丸
抑郁症
行为学指标
5-羟色胺
皮质醇
Depressed Syndrome
Yueju Pill
Depressive Disorder
the index of ethology
5-HT
Cortisol
