摘要
目的探讨维吾尔族类风湿关节炎(RA)患者外周血中miR-155的表达水平及其与RA疾病活动度的相关性。方法选取在新疆医科大学附属中医医院风湿科就诊的维吾尔族初发RA患者30例(RA组)及健康体检者30例(对照组),采用实时荧光定量PCR法检测2组外周血中miR-155的相对表达量,并且与RA患者临床指标进行相关性分析。结果 miR-155在RA组外周血中的相对表达水平(1.24±0.31)较对照组(1.02±0.21)明显升高,差异有统计学意义(t=3.27,P=0.0019)。RA组外周血中miR-155的相对表达量与类风湿关节炎患者病情评价(DAS28评分)、C-反应蛋白(CRP)、血沉(ESR)、血小板、病程、关节功能分级等临床指标无相关性(P>0.05)。结论维吾尔族RA患者外周血中miR-155的表达上调,其表达水平与RA疾病活动度无相关性。
Objective To investigate the expression level of miR-155 in the peripheral blood of Uygur pa-tients with rheumatoid arthritis （RA） and to analyze the correlation with RA disease. Methods The ex-pression level of miR-155 in the peripheral blood was measured using real-time RT-PCR in 30 cases of Uygur patients with RA and 30 healthy controls. The correlation between miR-155 expression and RA dis-ease was analyzed. Results The expression level of miR-155 in the peripheral blood of Uygur patients with RA was shown to be increased significantly （P 〈C0.01） compared to healthy controls. No significant corre-lation was observed between the relative expression of MiR-155 and DAS28 score, C-reactive protein, blood sedimentation, platelet, duration of symptom, and joint function grading （P 〉0.05）. Conclusion The expression of miR-155 in peripheral blood of Uygur patients with RA was displayed to be up-regula-ted, and its expression level was found to be not correlated with RA disease activity.
出处
《新疆医科大学学报》
CAS
2017年第7期906-908,940,共4页
Journal of Xinjiang Medical University
基金
新疆医科大学科研创新基金(XJC2013141)
