摘要
目的分析重症监护病房(ICU)感染患者血尿酸(BUA)水平与其预后的相关性,为制订有效临床治疗方案提供依据。方法选取2014年6月-2016年6月在ICU发生感染153例患者为研究对象,根据患者的预后将其分为死亡组(49例)、好转组(77例)和治愈组(27例),对所有患者的感染部位、入ICU治疗24h内的急性生理与慢性健康评分(APACHEⅡ评分)、BUA、血肌酐(Scr)、血尿素氮(BUN)水平进行回顾性分析。结果死亡组、好转组、治愈组患者APACHEⅡ评分分别为(44.03±12.06)、(24.12±13.67)、(13.95±4.08),BUA水平分别为(0.29±0.14)mmol/L、(0.22±0.12)mmol/L、(0.17±0.10)mmol/L,Scr水平分别为(5.36±3.03)mmol/L、(5.11±1.75)mmol/L、(4.22±1.05)mmol/L,BUN分别为(81.83±14.62)μmol/L、(79.57±13.24)μmol/L、(72.43±11.48)μmol/L,3组患者APACHEⅡ评分、BUA水平、Scr水平、BUN水平的差异均有统计学意义(P<0.05),其中,死亡组患者上述指标水平均高于好转组或治愈组,好转组患者APACHEⅡ评分、BUA水平高于治愈组,差异均有统计学意义(P<0.05);logistic多元回归分析结果显示,ICU感染患者死亡与年龄、APACHEⅡ评分、BUA水平具有相关性(P<0.05)。结论 ICU感染患者BUA水平与感染部位、患者预后具有一定的相关性,可作预测患者预后的参考指标。
OBJECTIVE To analyze correlation between the blood uric acid（BUA）level and prognosis of infected patients in intensive care unit（ICU）,so as to provide basic data for formulating effective clinical treatments.METHODS A total of 153 patients complicated with infection hospitalized in ICU from Jun.2014 to Jun.2016 were selected as research subjects,and were divided into death group（49cases）,improvement group（77cases）and cured group（27cases）according to the prognosis of the patients.The infection sites,and the acute physiology and chronic health evaluation（APACHEⅡ）score,BUA level,serum creatinine（Scr）level,blood urea oxygen（BUN）level within 24 hof ICU treatment of the patients in the three groups were retrospectively analyzed.RESULTS APACHEⅡ scores of the patients in death group,improvement group and cured group were（44.03±12.06）,（24.12±13.67）and（13.95±4.08）,respectively,BUA levels were（0.29±0.14）mmol/L,（0.22±0.12）mmol/L and（0.17±0.10）mmol/L,respectively,Scr levels were（5.36±3.03）mmol/L,（5.11±1.75）mmol/L and（4.22±1.05）mmol/L,respectively,and BUN levels were（81.83±14.62）μmol/L,（79.57±13.24）μmol/L and（72.43±11.48）μmol/L,respectively.There were statistically significant differences of APACHEⅡscores,BUA levels,Scr levels,and BUN levels among the three groups（P〈0.05）.These indexes of the patients in death group were significantly better than those in improvement group and curing group,the APACHEⅡscore and BUA level of improvement group were significantly higher than those in cured group,and the differences were statistically significant（P0.05）.Logistic multivariate regression analysis showed that the death of the infected patients in ICU was correlated with age,APACHEⅡ score or BUA level（P0.05）.CONCLUSIONBUA level of the infected patients in ICU is related to the infection site and the prognosis of the patients,which can be used as a marker to predict the prognosis of the patients.
作者
王雪娇
胡志华
朱雪丽
陈伟
陈志林
WANG Xue-jiao HU Zhi-hua ZHU Xue-li CHEN Wei CHEN Zhi-lin(First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 3570102, China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第4期781-784,共4页
Chinese Journal of Nosocomiology
基金
海南省教育厅科研基金资助项目(Hnky2015-35)
海南省自然科学基金资助项目(20168302)
关键词
重症监护病房
医院感染
血尿酸
预后
相关性分析
Intensive care unit
Nosocomial infection
Blood uric acid
prognosis
Correlation analysis
