摘要
目的研究淤胆型婴儿肝炎综合征在患儿治疗前后血清γ-谷氨酰转移酶(GGT)的变化,与探讨血清GGT和黄疸程度相关性及治疗后反应。方法淤胆型婴儿肝炎综合征62例根据最初的黄疸直接胆红素(DB)高低分组:≤136.8μmol/L(组Ⅰ)30例,>136.8μmol/L(组Ⅱ)32例。予常规保肝退黄治疗,治疗前后常规进行血生化检测。结果组ⅡALT及碱性磷酸酶(ALP)指标略高于组Ⅰ,但二者之间差异无显著性,而二组GGT差异有显著性,在组ⅡGGT水平明显升高。治疗后总胆红素(TB)及DB明显下降,ALT及ALP指标也表现为下降,组Ⅱ和组ⅠGGT水平在治疗前后差异显著,GGT水平与TB及DB均呈显著正相关。结论GGT可作为淤胆型婴儿肝炎综合征患者胆汁淤积的敏感指标之一;动态观察淤胆型婴儿肝炎综合征患者GGT变化是婴儿肝炎综合征治疗中的一项重要指标,是判断病情和预后敏感的指标。
Objective To investigate changes of serum gamma glutamyhransferase（GGT） before and after treatment in infant with infantile cholestatic hepatitis syndrome, and to study the relationship between serum GGT and jaundice. Methods Sixty - two children with infantile cholestatic hepatitis syndrome were divided into 2 group according to the level of direct bilirubin（DB） ：30 cases with serum DB under 136.8 μmol/L（group Ⅰ ） ,and 32 cases with serum DB higher than 136.8 μmol/L（group Ⅱ ）. All the patients were treated with routine methods, and serum biochemistry was adopted before and after treatment. Results The levels of ALT and alkaline phosphatase （ALP） were lightly higher,but there was no statistical significance,in group Ⅱ compared with that in group Ⅰ ,whereas the difference of GGT between these 2 groups had statistical significance. Total bilirubin （ TB）, DB, ALT and ALP were decreased in 2 groups after routine treatment, the same conditions with GGT, and positive correlation was found between GGT, TB and DB. Conclusions GGT can be a sensitive index of cholestasis in infantile cholestatic hepatitis syndrome, and its change will be a good overview during the therapy. It also contributes to prognosis judgement of infantile cholestatic hepatitis syndrome.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第7期490-491,共2页
Journal of Applied Clinical Pediatrics
基金
江苏省科技厅社会发展计划项目资助(BS2005606)
关键词
肝炎综合征
婴儿
Γ-谷氨酰转移酶
胆汁淤积
eholestatie hepatitis syndrome, infant
gamma glutamyhransferase
eholestasis
