摘要
目的探讨社区居民高尿酸血症(HUA)和高血压的发病情况及其相关关系,为有效防治尿酸相关心血管疾病提供依据。方法对6273例18～75岁的桂林市象山区城市社区居民进行横断面调查,收集空腹血及晨尿进行血糖、肾功能、胰岛素和高敏C反应蛋白等检测,同时进行问卷调查和体格检查。结果在社区居民中HUA的平均患病率为23.5%,男性为28.4%,高于女性的19.7%(P<0.01)。平均高血压患病率为27.8%,其中HUA组为37.8%,正常尿酸组为24.7%(P<0.01)。高尿酸者高血压风险约为尿酸正常者的1.8倍,其中在30岁以下组约为3.3倍,在30～60岁组约为2.1倍,60岁以上组差异不明显。在第3和第4四分位尿酸水平组,高血压患病率明显增高,尤其以收缩压增高为主。用血肌酐、年龄和性别校正后,血尿酸水平与收缩压、舒张压和高敏C反应蛋白等因素有关(P<0.01)。结论高尿酸居民高血压的患病率明显增高,尤其是在年轻人群中,主要影响收缩压。尿酸可能通过微炎症反应介导高血压的发生。
Objective To study the prevalences of hyperuricemia（HUA）and hypertension in community residents and the association between them,to look for the methods for effective prevention of uric acid associated cardiovascular diseases.Methods A total of 6273 urban community residents,aged 18-75 years old,received cross-sectional investigation in Xiangshan District,Guilin City.Fasting blood glucose and urine samples were collected for evaluating blood glucose level,renal function,and levels of insulin,high-sensitivity C-reactive protein.Questionnairing and physical examination were performed at the same time.Results The prevalence of HUA was 23.5%,28.4% in the males,which was significantly higher than 19.7% in the females（P 0.01）.The prevalence of hypertension was 27.8%,37.8% in the hyperuricemia（HUA）residents,which was significantly higher than 24.7% in the residents with normal uric acid level（P 0.01）.For all the residents,the relative risk（RR）for hypertension in the hyperuricemia residents was 1.8 times higher than the residents with normal uric acid level.The RR was 3.3 times higher in residents younger than 30 years old,2.1 times higher in residents between 30-60 years old,but not significantly different in residents older than 60 years old.The prevalence of hypertension was significantly higher in the residents with uric acid level over the 50 percentile when compared to those below the 50 percentile,especially the prevalence of elevated systolic blood pressure.After adjusting for serum creatinine,age and gender,the uric acid level was positively related to the levels of systolic blood pressure,diastolic blood pressure and high-sensitivity C-reactive protein（P 0.01）.Conclusion In the residents with HUA,the prevalence of hypertension is higher than those with normal uric acid level,especially in the younger residents.The main influence of hyperuricemia on the blood pressure is the increasing the prevalence of elevated systolic blood pressure.The higher prevalence of hypertension in hyperuricemi
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2011年第2期148-152,共5页
Chinese Journal of Hypertension
基金
广西科学研究与技术开发计划项目(桂科攻0719006-2-29)
关键词
高尿酸血症
高血压
社区筛查
患病率
危险因素
Hyperuricemia
Hypertension
Community epidemic investigation
Prevalence
Risk factors
