摘要
本文通过低氧引发破骨前体细胞内部信号通路网络,表明骨吸收的部位的局部低氧环境可增强破骨细胞活性,提高其骨吸收功能。目前,低氧促进破骨细胞分化与功能的分子机制尚不明确,因此,为深入研究低氧引发破骨前体细胞内部信号通路网络,探讨低氧诱导因子促进破骨细胞分化及骨吸收的分子机制。
Osteoclast plays a key role in bone resorption. Previous studies showed that local hypoxia in resorption sites enhances activity of osteoclast and increases its function of bone resorption. However, the molecular mechanism of hypoxia in promoting osteoclast differentiation and function is unclear. By reviewing hypoxia triggering the internal signal path network in osteoclast precursor cells, this article aims to provide new ideas for the in-depth study on hypoxia inducible factor in promoting osteoclast differentiation and the associated molecular mechanisms of bone resorption ability, and to provide molecular targets for the clinical treatment of periodontitis and periapical periodontitis and other bone resorption diseases.
出处
《口腔颌面修复学杂志》
2016年第5期313-315,共3页
Chinese Journal of Prosthodontics
基金
国家自然科学基金(项目编号:81260161
81000460)
关键词
低氧
低氧诱导因子
破骨细胞
骨吸收
hypoxia
hypoxia inducible factor
osteoclast
bone resorption
