摘要
目的观察定痛汤对无先兆性偏头痛病人血中降钙素基因相关肽(CGRP)和P物质(SP)的影响及临床疗效。方法将60例无先兆性偏头痛病人随机分成两组,治疗组30例给予定痛汤治疗,对照组30例给予盐酸氟桂利嗪胶囊治疗。两组疗程均为15d。采用酶联免疫吸附测定(Elisa)检测病人血中CGRP和SP含量。结果治疗组总有效率90.0%,对照组总有效率65.6%,两组总有效率比较差异有统计学意义(P<0.05)。两组血中CGRP和SP含量的差异有统计学意义(P<0.01),CGRP和SP含量均有不同程度的降低,但治疗组血中CGRP和SP含量下降的程度较对照组更加明显(P<0.05)。结论定痛汤可以明显提高无先兆偏头痛的临床疗效,且可以降低偏头痛病人血中CGRP和SP含量。
Objective To observe the influence and clinical efficacy of Dingtong decoction（DTD）on calcitonin gene-related peptide（CGRP）and substance P（SP）in patients with migraine without aura.Methods Sixty patients with migraine without aura were randomly divided into two groups：control group（n =30）treated with flunarizine hydrochloride capsules,and treatment group（n =30）treated with DTD for 15 days.The levels of CGRP and SP were measured with enzyme-linked immuno sorbent assay（ELISA）method.Results The total effective rate in treatment group was higher than that in control group（90.0%vs 65.6%,P〈0.05）.The content of CGRP and SP were decreased in two groups（P〈0.01）.However,the effect of the treatment group was more obvious than the control group（P〈0.05）.Conclusion DTD can increase clinical effect,and decrease the content of CGRP and SP in patients with migraine without aura.
出处
《中西医结合心脑血管病杂志》
2016年第18期2101-2103,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
贵州省科学技术基金项目(No.20112245)
关键词
无先兆偏头痛
定痛汤
降钙素基因相关肽
P物质
migraine without aura
Dingtong decoction
calcitonin gene-related peptide
substance P
