摘要
目的:探讨百灵调肝汤加减治疗多囊卵巢综合征(PCOS)不孕症肝郁气滞型的疗效以及对血清游离脂肪酸(FFA),C反应蛋白(CRP)和β-内啡肽(β-EP)水平的影响。方法:共选择符合条件的110研究对象,按随机数字表法分为观察组和对照组各55例;对照组采取炔雌醇环丙孕酮片和枸橼酸氯米芬胶囊促排卵治疗;观察组在对照组治疗的基础上采取百灵调肝汤加减内服治疗,1剂/d,常规水煎煮2次,分早晚2次内服;两组患者治疗均4个月经为1周期。比较两组临床症状评分以及子宫内膜厚度和卵巢体积;记录两组6个月经周期(MC)临床妊娠率;检测两组治疗前后血清FFA,CRP和β-EP水平。结果:观察组治疗后中医症状各指标评分均明显低于对照组(P<0.01);在6个月经周期内,观察组的临床妊娠率为60%,对照组为36.36%,观察组高于对照组(P<0.05);观察组治疗后子宫内膜厚度高于对照组,而卵巢体积低于对照组(P<0.01);治疗后观察组血清FFA和CRP水平均低于对照组,而β-EP高于对照组,比较差异有统计学意义(P<0.01)。结论:在对照组治疗的基础上,百灵调肝汤加减治疗PCOS不孕症肝郁气滞型可明显改善患者临床症状,增加子宫内膜厚度同时减少卵巢体积,提高临床妊娠率,其作用机制可能与降低患者血清FFA和CRP以及增加β-EP水平有关。
Objective： To investigate the clinical efficacy of Bailing Tiaogan decoction in treating infertilitas feminis of liver Qi stagnation type polycystic ovary syndrome（ PCOS）,and observe its effects on levels of free fat acid（ FFA）,C-reactive protein（ CRP） and β-endorphin（ β-EP） in serum. Method： One hundred and ten eligible patients were randomly divided into control group（ 55 cases） and observation group（ 55 cases） by random number table. Patients of control group were given with ethinylestradiol and cyproterone acetate tablets and clomiphene citrate capsules for ovulation induction. The patients in observation group were treated with Bailing Tiaogan decoction（ 1 dose / day,bid） by oral administration based on the observation of control group. The treatment course was four menstrual cycles for both groups. Scores of clinical symptoms,endometrial thickness,and ovarian volume were compared between two groups. Clinical pregnancy rate was recorded within six menstrual cycles（ MCs） for both groups. The levels of FFA,CRP and β-EP in serum were detected pre-post treatment in two groups. Result： Traditional Chinese medicine（ TCM） symptom scores in treatment group were lower than those in control group after treatment（ P 〈0. 01）. Within six MCs,the clinical pregnancy rate was 60% in observation group,significantly higher than 36. 36% in control group（ P 〈0. 05）. The endometrial thickness in treatment group was significantly higher than that in control group after treatment,while the ovarian volume was significantly lower than that in control group（ P 〈0. 01）. The levels of FFA and CRP in serum of observation group were significantly lower than those of control group after treatment,while β-EP level was significantly higher than that of control group,with statistically significant differences（ P 〈0. 01）. Conclusion： On the basis of control group treatment,Bailing Tiaogan decoction could significantly improve clinical symptoms,increase endometrial thickne
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第13期165-168,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
河南省中医药科学研究专项课题(2013ZY02035)
关键词
百灵调肝汤
多囊卵巢综合征
肝郁气滞型
不孕
Bailing Tiaogan decoction
polycystic ovary syndrome
liver Qi stagnation
infertilitas feminis
