摘要
目的:观察补肾调经育子汤合二甲双胍治疗多囊卵巢综合征(polycystic ovarian syndrome,PCOS)所致不孕的临床疗效。方法:36例PCOS所致不孕患者随机平均分为观察组和对照组。对照组给予二甲双胍治疗,观察组在对照组治疗基础上给予补肾调经育子汤。比较两组患者临床疗效、激素水平、妊娠率及不良反应等。结果:观察组有效率为94.44%,对照组为66.67%,两组有效率比较,差异有统计学意义(P<0.05)。治疗后,两组患者的黄体生成素(luteinizing hormone,LH)、卵泡刺激素(follicle-stimulating hormone,FSH)、睾酮(testosterone,T)及催乳素(prolactin,PRL)水平均低于治疗前(P<0.05),且观察组治疗后以上指标治疗后均低于对照组治疗后(P<0.05)。观察组的成熟卵泡排卵率、月经周期改善率、卵泡发育改善率及子宫内膜厚度等临床指标均优于对照组,差异均有统计学意义(P<0.05)。观察组的生化妊娠率、临床妊娠率均高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者胰岛素抵抗指数(homeostasis model assessmentinsulin resistance index,HOMA-IR)均低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。观察组不良反应发生率为11.11%,对照组为44.44%,两组比较,差异有统计学意义(P<0.05)。结论:补肾调经育子汤合二甲双胍治疗PCOS所致不孕临床疗效显著,可明显降低患者LH、FSH、T及PRL水平,改善成熟卵泡排卵、月经周期、卵泡发育及子宫内膜厚度等临床指标,提高生化妊娠率、临床妊娠率,降低HOMA-IR,且不良反应较少。
Objective ： To investigate the clinical efficacy of Bushen Tiaojing Yuzi Decocion combined with metformin in treatment of infertility caused by polycystic ovary syndrome（PCOS）. Methods ：36 patients with infertility caused by PCOS were randomly divid- ed into control group and observation group. The control group was given metformin in treatment. The observation group was given Bushen Tiaojing Yuzi Decoction on the basis of the control group. The clinical efficacy, hormone levels, pregnancy rates, adverse reactions of the two groups of patients were compared. Results： The effective rate was 94.44% in the observation group and 66. 67% in the control group. There was a statistically significant difference between the two groups （P 〈 0.05 ）. After treatment, luteinizing hormone （LH）,follicle-stimulating hormone （FSI4）,testosterone （T） and prolactin （PRL） levels of both groups were lower than before （P 〈 0.05） and the above indexes in the observation group were all lower than those in the control group after treatment （P 〈 0.05 ）. The clinical indexes of mature follicle ovulation rate, menstrual cycle improvement rate, fbllicular develop- ment improvement rate and endometrial thickness in the observation group were better than those in the control group, and the differences were statistically significant（P 〈 0.05 ）. The biochemical pregnancy rate and clinical pregnancy rate of the observation group were higher than those of the control group, and the differences were statistically significant（P 〈0.05 ）. After treatment,the homeostasis model assessment- resistance index （HOMA-IR） was lower （P 〈 0.05 ） in both groups, and the observation group was lower than the control group （P 〈 0. 05 ）. The occurrence of the adverse reactions wasl 1. 11% % in the observation group and 44. 44% in the control group. There was a significant difference between the two groups （P 〈 O. 05 ）. Coaclusion ： Bushen Tiaojing Yuzi Decocion combined with metformin in t
作者
申小静
杨光
李爱香
马志远
潘成学
SHEN Xiaojing;YANG Guang;LI Aixiang;MA Zhiyuan;PAN Chengxue(Henan Institute of Population and Family Planning Science and Technology,Zhengzhou Henan China 450002;Zhengzhou University,Zhengzhou Henan China 450001)
出处
《中医学报》
CAS
2018年第9期1759-1762,共4页
Acta Chinese Medicine
基金
河南省属科研院所基本科研业务费专项资金项目(JBKY2015016
JBKY2016204)
关键词
补肾调经育子汤
二甲双胍
多囊卵巢综合征
黄体生成素
卵泡刺激素
睾酮
催乳素
胰岛素抵抗指数
中西医结合
Bushen Tiaojing Yuzi Decoction
metformin
polycystic ovary syndrome
luteinizing hormone
follicle stimulating hor-mone
testosterone
Prolactin
insulin resistance index
integration of traditional and western medicine
