摘要
目的:探索冻融胚胎移植后12 d的孕母血清β-HCG水平对早孕期妊娠结局的预测方法。方法:回顾性分析2013年1月至2014年12月在南方医科大学南方医院妇产科生殖医学中心进行的冻融胚胎移植后抽血显示妊娠的患者248例,分为早期妊娠终止组136例和继续妊娠组112例。比较两组的基本特征,并对所有患者进行分类树分析。结果:两组在年龄、BMI、对应取卵周期的HCG日E2水平、获卵数和受精数的差异无统计学意义(P>0.05)。两组冻融胚胎移植周期开始黄体支持前E2、P、子宫内膜厚度和胚胎移植数的比较差异无统计学意义(P>0.05)。HRT-FET后12 d,血清β-HCG>298.60和≤70.71 IU/L,分别可预测妊娠12周是否继续妊娠。结论:根据HRT-FET后12 d孕母血清β-HCG的值可以预测早孕期妊娠结局,有助于咨询建议和分类管理患者。
Objective To explore the predictive method of β-HCG level in pregnant women for pregnancy outcomes in first trimester in the 12 days after frozen thawed embryo transfer cycle. Methods A retrospective analysis was performed on 248 pregnant patients between January 2013 and December 2014, who were transferred with frozen thawed embryos in Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University. They were divided into early pregnancy termination group（n = 136） and the ongoing pregnancy group（n = 112）. The general data of the two groups were compared and classification tree analysis was established. Results There were no significant differences in age, BMI, E2 level at HCG injection of the corresponding ooctye retrieval cycle, number of oocytes collected and number of oocytes fertilized in the corresponding ooctye retrieval cycle（P〉0.05）. There was no significant difference in E2, P, endometrial thickness and the number of embryos transferred between two groups（P〉0.05）. D12 β-HCG level of HRT-FET（D12β-HCG） 〉298.60 and ≤70.71 IU / L can predict whether or not the pregnancy continues at week 12. Conclusions D12 β-HCG level can predict pregnancy outcomes in first trimester in HRTFET cycles. These help to consultation and classified management.
出处
《实用医学杂志》
CAS
北大核心
2016年第9期1415-1418,共4页
The Journal of Practical Medicine
基金
国家自然科学基金资助项目(编号:81170574
81401177)
广东省自然科学基金资助项目(编号:2015A030313286)
关键词
冻融胚胎移植
Β-HCG
早期流产
Frozen thawed embryo transfer
β-human chorionic gonadotropin
Early abortion
