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血清PAPP-A、β-hCG与妊娠期糖尿病及不良妊娠结局关系 被引量:12

Correlation between serum pregnancy-associated plasma protein-A andβ-hCG levels of pregnant women and their occurrence of gestational diabetes mellitus and adverse pregnancy outcomes
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摘要 目的:观察血清妊娠相关蛋白A(PAPP-A)、人绒毛膜促性腺激素(β-hCG)水平与妊娠期糖尿病(GDM)及不良妊娠结局的关系。方法:回顾性收集2017年1月-2020年1月本院发生GDM与不良妊娠结局孕妇140例临床资料为观察组,根据妊娠结局确定不良妊娠类型,同期健康且妊娠结局良好初产妇140例为对照组,比较各组血清PAPP-A、β-hCG水平及相关性。结果:GDM组与不良妊娠结局组血清PAPP-A水平低于对照组,胎儿宫内发育不良及先兆流产孕妇血清β-hCG水平高于对照组,异位妊娠孕妇β-hCG水平低于对照组(均P<0.05);相关性分析,血清PAPP-A水平与GDM、胎儿宫内发育不良、异位妊娠及先兆流产呈负相关,血清β-hCG水平与GDM、胎儿宫内发育不良、先兆流产呈正相关,与异位妊娠呈负相关(均P<0.05)。结论:血清PAPP-A、β-hCG水平与GDM及不良妊娠结局有关,可能作为临床评估GDM及不良妊娠结局风险指标。 Objective: To observe correlation between serum serum pregnancy-associated plasma protein-A(PAPP-A) and human chorionic gonadotropin(β-hCG) levels of pregnant women and their occurrence of gestational diabetes mellitus(GDM) and adverse pregnancy outcomes. Methods: The clinical data of 140 pregnant women with GDM and adverse pregnancy outcomes from January 2017 to January 2020 in observation group were collected retrospectively, and their type of adverse pregnancy was identified according to the pregnancy outcomes. 140 healthy primiparas with good pregnancy outcomes were selected in control group during the same period. The levels of serum PAPP-A and β-hCG of the women were compared between the two groups. Correlation analysis was performed. Results: The serum PAPP-A level of the women in the observation group was significant lower than that of the women in the control group. The serum β-HCG level of the pregnant women with threatened abortion or fetal intrauterine dysplasia in the observation group was significant higher than that of the women in the control group(P<0.05), but the serum β-HCG level of the pregnant women with ectopic pregnancy in the observation group was significant lower than that of the women in the control group(all P<0.05). Correlation analysis showed that serum PAPP-A level was negatively correlated with the rates of GDM, fetal intrauterine dysplasia, ectopic pregnancy, and threatened abortion, while serum β-HCG level was positively correlated with the rates of GDM, fetal intrauterine dysplasia and threatened abortion, and serum β-HCG level was negatively correlated with ectopic pregnancy rate(all P<0.05). Conclusion: The levels of serum of PAPP-A and β-hCG are closely related to the occurrence of GDM and adverse pregnancy outcomes, which may be applied as indexes for evaluating the risk of GDM and adverse pregnancy outcomes.
作者 贾秦亮 郭晓波 JIA Qinliang;GUO Xiaobo(Northwest Women's and Children's Hospital,Xi'an,Shaanxi Province,710061;Xi'an Central Hospital Affiliated to Xi'an Jiaotong University)
出处 《中国计划生育学杂志》 2021年第6期1263-1265,1269,共4页 Chinese Journal of Family Planning
基金 陕西省重点研发计划项目(2018SF-205)。
关键词 妊娠期糖尿病 不良妊娠结局 妊娠相关蛋白A 人绒毛膜促性腺激素 风险评估 Gestational diabetes mellitus Adverse pregnancy outcomes Pregnancy-associated plasma protein-A Human chorionic gonadotropin Risk evaluation
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