摘要
目的:探讨胚胎移植后14天与16天检测双次血人绒毛膜促性腺激素(β-HCG)及其倍数增长情况对妊娠结局的预测价值。方法:分析体外受精-胚胎移植助孕治疗的452例患者的临床资料,将妊娠妇女分为正常妊娠组(320例)、异常妊娠组(32例)、生化妊娠组(100例)。正常妊娠组包括单胎妊娠、双胎妊娠和三胎妊娠;异常妊娠组包括单胎停育和异位妊娠。比较胚胎移植后14天与16天血β-HCG浓度(简写HCG14d和HCG16d)的中位数水平及其倍数增长(简写HCG16d:14d)情况。结果:HCG14d与HCG16d的中位数水平从异常妊娠至正常妊娠逐渐增加。正常妊娠组的HCG14d、HCG16d及HCG16d:14d均明显高于异常妊娠组,差异有高度统计学意义(P=0.000),界值分别为380.59U/L、807.26U/L和2.10时均有中等预测价值;多胎妊娠组的HCG14d、HCG16d高于单胎妊娠组,差异有高度统计学意义(P=0.000),界值分别为1231.73U/L、3053.49U/L时有中等预测价值,其HCG16d:14d略高于单胎妊娠组,差异无统计学意义(P=0.857),界值为2.48时有较少预测价值;单胎停育组的HCG14d、HCG16d及HCG16d:14d均低于单胎妊娠组,差异均有统计学意义(P=0.034,P=0.001,P=0.000),界值分别为192.30U/L、366.46U/L和1.94时,分别有较少、中等、较高的预测价值;异位妊娠组的HCG14d、HCG16d及HCG16d:14d均低于单胎妊娠组,差异均有高度统计学意义(P=0.000,P=0.000,P=0.001),界值分别为110.36U/L、264.23U/L和1.97时分别有较高、较高、中等的预测价值。结论:胚胎移植后HCG14d、HCG16d定量检测结合其HCG16d:14d倍数增长可以预测正常妊娠、胚胎停育和异位妊娠。
Objective：To assess the predictive value of a double serum β-HCG determination combined with its multiple in pregnancy outcome after embryo transfer（ET）. Methods ：452 IVF-ET cases were enrolled in this analysis and included viable pregnancy group （320 cases）, non-viable pregnancy group （32 cases）, and biochemical pregnancy group （ 100 cases）. Viable pregnancy included single-pregnancy,twin-pregnancy, and triplet-pregnancy. Non-viable pregnancy included first-trimester miscarriage and ectopic pregnancy. The median of serum β-HCG level on 14^th day and 16^th day following ET and the multiple （HCG 16d： 14d ）were re- corded retrospectively. Results：The HCG14d 、HCG16d and HCG 16d： 14d in viable pregnancy group were all sig- nificantly higher than those in non-viable pregnancy group （ P = 0. 000）. The cut-off values of HCG14d, HCG 16d and HCG 16d： 14d were 380. 59 U/L,807.26 U/L,2. 10, respectively, which were all moderate predictive val- ues. The HCG14d and HCG16d in multiple pregnancy group were both higher than those in single pregnancy group（ P =0. 000）, and the cut-off values were 1231.73 U/L and 3053.49 U/L, respectively. The HCG 14d,HCG16d and HCG16d： 14d in first-trimester miscarriage group were all significantly lower than those in single pregnancy group （ P = 0. 034, P = 0. 001, P = 0. 000 ）. The cut-off values were little, moderately, highly predic- tive value respectively,which the HCG14、HCG 16d and HCG 16d： 14d were respectively 192.30 U/L,366.46 U/ L、1. 94. The HCG14d ,HCG16d and HCG 16d： 14din ectopic pregnancy group were all lower than those in single pregnancy group（ P = 0. 000, P = 0. 000, P = 0. 001 ）, and the cut-off values were highly, highly, moderately predictive value respectively, which the HCG 14d 、 HCG 16d and HCG 16d： 14d were respectively 110. 36 U/L 264. 23 U/L、1. 97. Conclusions.The serum β-HCG quantitative determination on day 14 and day 16 after ET combined with the multiple（ HCG 16d： 14d）might be of some predict
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2012年第11期942-946,共5页
Journal of Practical Obstetrics and Gynecology
关键词
人绒毛膜促性腺激素
体外受精-胚胎移植
倍数
妊娠结局
In vitro fertilization and embryo transfer
Human chorionic gonadotrophin
Multiple
Pregnan-cy outcome
