摘要
目的:分析全胚冷冻对体外受精/卵泡浆内单精子注射-胚胎移植(IVF/ICSI-ET)临床结局的影响。方法:回顾性分析2012年9月至2013年8月我院生殖医学中心489个移植周期的临床资料,其中214个全胚冷冻后首次冻融移植周期(F-ET)为A组,275个新鲜移植周期为B组,并根据移植胚胎发育阶段将各组进一步分为囊胚移植组(A1组,B1组)和卵裂胚移植组(A2组,B2组),比较各组的临床结局。结果:A1组临床妊娠率和胚胎种植率(71.1%、53.0%)显著高于A2、B1和B2组(分别为:57.3%、34.0%;55.0%、42.1%;52.9%、32.7%)(P<0.05),B1组的胚胎种植率高于B2组(P<0.05)。结论:全胚冷冻可明显提高首次冻融移植周期临床妊娠率和胚胎种植率,冻融囊胚移植可获得比冻融卵裂胚移植更好的临床结局。
Objective To analyze the outcomes of frozen-thawed blastocyst and cleavage embryo transfer after whole embryos cryopreservation. Methods The data of 489 IVF-ET cycles in reproductive medicine center of our hospital from September 2012 to August 2013 were analyzed retrospectively. Whole embryos cryopreservation in 214 patients were carried out with vitrification method and served as group A , 275 cycles performed fresh embryo transfer were served as group B. Then group A and group B were subdivided into group A1 （83 cycles）,group A2 （131 cycles）, group B1 （120 cycles）and group B2 （155 cycles）according to blastocyst transfer or cleavage-stage embryo transfer. The clinical outcomes of all groups were compared each other. Results The pregnancy rate and embryo implantation rate in group A1 were significantly higher（71.1% ,53.0%）than those in group A2, B1 and B2 （A2 group： 57.3%, 34.0%, B1group： 55.0%,42.1%, B2 group： 52.9%, 32.7%,respectively）（P〈0.05）. The embryo implantation rate in group B1 were higher than those in group B2 （P 〈 0.05）. Conclusion F-ET after whole embryos freezing could significantly improve the embryo utilization rate and clinical pregnancy rate. Frozen-thawed blastocyst transfer could get better clinical outcomes than frozen-thawed cleavage-stage embryo transfer.
出处
《实用医学杂志》
CAS
北大核心
2014年第16期2580-2582,共3页
The Journal of Practical Medicine
关键词
全胚冷冻
囊胚
卵裂胚
临床结局
Whole embryos cryopreservation
Blastocyst
Cleavage-stage embryo
Clinical outcomes
