摘要
心房颤动(atrial fibrillation,AF)是临床最常见的心律失常之一。尽管近年来在AF管理和预防方面取得了很大的进展,但AF仍有很高的发病率,导致患者反复住院,影响其生活质量,甚至导致死亡,造成了巨大的社会和经济负担。迄今为止,AF的发生机制尚未完全阐明,有多种复杂的机制参与了AF的发生与持续。目前,有大量证据显示炎症与AF密切相关,炎症可能通过影响心脏的电重构和结构重构,参与了AF的发生与持续。本文对炎症与AF相关性证据以及AF的抗炎药物治疗研究进展进行综述。
Atrial fibrillation（AF）is one of the most common cardiac dysrhythmia encountered in clinical practice. Although major advances in management and prophylaxis in recent years, AF continues to be associated with increased morbidity, repeated hospitalization, reduced quality of life, and even death, causing great social and economic burden. So far, the mechanism underlying AF is not completely elucidated. There is an enormous and complicated pathogenesis involved in the occurrence and maintenance of AF. At present, a lot of studies show that inflammation is closely associated with AF. Inflammation may take part in the occurrence and maintenance of AF through the influence of cardiac electrical remodeling and structural remodeling. This review focuses on research progress of correlation evidence of inflammation and atrial fibrillation and anti-inflammatory drug therapies of AF.
出处
《中国胸心血管外科临床杂志》
CAS
CSCD
2016年第1期72-77,共6页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
基金
辽宁省科学技术攻关项目(2012225005)~~
关键词
心房颤动
炎症
上游治疗
Atrial fibrillation
Inflammation
Upstream therapies
