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缝隙连接重塑与心律失常上游治疗 被引量:3

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摘要 心律失常是心脏疾病最主要的临床表现之一,其危害不仅在于心律失常本身,还可加重原有的基础心脏疾病,如心功能不全、心肌缺血等,甚至引发心源性猝死(SCD).据统计,中国每年约有54.4万人死于心源性猝死,其中90%以上由恶性心律失常所致.心肌重塑可导致心脏扩大和心功能不全,也可导致心脏的电重构,后者反过来促进心肌的重塑,形成恶性循环.在心肌重塑的过程中,缝隙连接重塑对心律失常的产生和维持起到关键性的作用.
出处 《承德医学院学报》 2016年第5期432-436,共5页 Journal of Chengde Medical University
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