摘要
目的:探讨雌激素受体β(ERβ)在喉癌中表达情况以及其与上皮细胞间质转化生物标志物(EMT)间的关系。方法:采用Picture MT-Pv9000免疫组织化学技术检测72例喉癌及8例癌旁组织中ERβ及EMT的表达情况。结果:ERβ在癌组织和癌旁组织表达阳性率分别为27.78%、25.00%,差异无统计学意义(P>0.05),E-钙黏着蛋白(E-cadherin)和β-连环素(β-catenin)的异常表达率分别为61.11%、76.39%。ERβ阳性表达与E-cadherin表达的缺失及β-catenin的核转位、TNM分期增高成负相关(P<0.05)。结论:ERβ表达与喉癌分化、临床分期、颈淋巴结转移密切相关,其阳性表达提示喉癌预后良好,其机制可能与E-cadherin、β-catenin的异常表达有关。
Objective：To detect the expression of ERβ in laryngeal carcinoma and the its correlation with the expression of epithelial-mesenchymal transition（EMT） specific biomarkers. Method：Picture MT-Pv9000 was used to detect ERβ and EMT in 72 cases of human aqueous laryngeal carcinoma and 8 cases of adjacent non-neoplastic laryngeal mucosa by immunohistochemistry. Result：The positive rates of ERβ in tumors and adjacent non-neoplas- tic laryngeal mucosa were 27.78% and 25.00%, respectively. The differences were not significant （P〉0.05）. The abnormal expression rates of E-cadherin and β-catenin were 61.11% and 76.39 % respectively. The expression of ERβ correlated negatively with the loss of E-cadherin, nuclear translocation of β-catenin and increased TNM stage. The differences were significant （P〈0.05）. Conclusion： The positive expressions of ERβ suggest a good prognosis in the differentiation, clinical stages and lymphatic metastasis of the laryngeal carcinoma. The underlying mechanism may be related with the abnormal expressions of E-cadherin and β-catenin.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2015年第10期921-924,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
喉癌
雌激素受体
EMT
E-钙黏着蛋白
Β-连环素
laryngeal carcinoma
estrogen receptor
epithelial mesenchymal transition
E-cadherin
β-catenin
