摘要
目的:探讨上皮钙黏蛋白和β-连环素在喉癌组织中的表达及其临床意义。方法:应用免疫组织化学PicTureTM二步法,检测上皮钙黏蛋白和β-连环素在喉癌组织和癌周正常喉组织中的表达。结果:60例喉癌患者中,上皮钙黏蛋白和β-连环素的异常表达率为55.00%(33/60)和66.67%(40/60),按喉癌的临床分期、颈部淋巴结转移情况分组比较,均差异有统计学意义(均P<0.05),喉癌的组织学分级比较,差异有统计学意义(P<0.01),喉癌的原发部位及患者的性别、年龄差异无统计学意义(P>0.05)。同一标本中上皮钙黏蛋白和β-连环素表达有显著的相关性和一致性(P<0.01)。结论:上皮钙黏蛋白和β-连环素的异常表达与喉癌分化、分期、转移密切相关。
Objective：To investigate the roles of E-cadherin and beta-catenin play in the carcinogenesis and progression of laryngeal carcinoma. Method： Immunohistochemistry staining （PicTure^TM two steps method） was used to detect E-cadherin and beta-catenin proteins expression in laryngeal carcinomas and normal epithelia around tumors. Result： In 60 laryngeal carcinomas, the abnormal expression rates of E-cadherin and beta-catenin were 55.00% and 66.67 % respectively. The significant relationship was observed between abnormal E-cadherin and beta-catenin expression and differentiation, clinical stage and lymph node metastasis. There was a positive relationship between the expression of beta-catenin and E-cadherin in same sample. Conclusion：The abnormal expression of E-cadherin and beta-catenin were closely related with differentiation, clinical stage, metastasis in laryngeal carcinoma.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2008年第10期459-461,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
