摘要
用氢氧化钾为催化剂,以水杨酸和乙酸酐为原料经O-酰化反应合成了乙酰水杨酸。通过正交试验探究了水杨酸与乙酸酐的物质的量比、反应时间和反应温度对催化合成的影响。实验结果表明,合成乙酰水杨酸的最优条件为:催化剂用量为水杨酸的4%,水杨酸与乙酸酐的物质的量比为1∶2,反应温度为65℃,反应时间为25 min,阿司匹林产率可达84.72%。该方法操作简单,经济环保,产品质量好,适用于工业化生产。
Acetylsalicylic acid was synthesized by O-acylating reaction from salicylic acid and acetic anhydride by potassium hydroxide. The molar ratio of salicylic acid and acetic anhydride, reaction time and reaction temperature were explored by orthogonal experiment. The results showed that optimal conditions of aspirin synthesis was as follows： potassium hydroxide as catalyst dosage 4% of salicylic acid, the molar ratio of salicylic acid and acetic anhydride 1：2, reaction time 25 minutes, reaction temperature 65℃ and the aspirin yield 84.72%. The method had the advantage of simplification, economy and no-pollution, good quality product, which wais suitable for industrial production.
出处
《黑龙江八一农垦大学学报》
2014年第6期81-83,92,共4页
journal of heilongjiang bayi agricultural university
基金
黄山学院科研基金资助项目(2012xkj006)
安徽省大学生创新创业训练项目(AH201310375027)
关键词
水杨酸
乙酸酐
乙酰水杨酸
催化
合成
正交试验
salicylic acid
acetic anhydride
acetylsalicylic acid
catalyze
synthesis
orthogonal experiment
