摘要
以乙酸钠作为催化剂,研究了阿司匹林的合成反应。实验考察了催化剂的用量、反应时间以及温度对阿司匹林收率的影响。结果表明乙酸钠有较好的催化活性。当乙酸钠用量为反应物总量的3%、反应温度为55℃、反应时间为50min时,合成收率可达81.9%。对以阿斯匹林和扑热息痛为原料合成贝诺酯的工艺进行了改进,考察了不同溶剂对贝诺酯收率的影响。结果表明,在甲苯-水反应介质中贝诺酯的收率可达90%。
Aspirin was synthesized with using sodium acetate as the catalyst. The dosage of the catalyst, the reaction time and temperature which had effects on the yield of aspirin was studied. The results showed that sodium acetate had better catalytic activity, when the dosage of sodium acetate in the system was 3%, reaction temperature was 55℃, reaction time was 50min, and the yield of aspirin could reach 81.9%. The synthesis process of benorilate which taken aspirin and acetaminophen as raw materials was improved and the effect of different solvents on the yield of benorilate was investigated. The yield of benorilate was up to 90% in the system of toluene-water medium.
出处
《化学与粘合》
CAS
2009年第6期33-35,共3页
Chemistry and Adhesion
关键词
贝诺酯
阿司匹林
相转移催化
Benorilate
aspirin
phase transfer catalysis
