摘要
研究了以乙酸酐和2-羟基苯甲酸为原料,以对甲基苯磺酸为催化剂合成2-乙酰氧基苯甲酸的清洁合成工艺,考察了影响合成反应的诸多因素。最佳工艺条件是:物质的量n的比为n(2-羟基苯甲酸)∶n(乙酸酐)∶n(对甲基苯磺酸)=1.0∶2.0∶0.025,反应温度为80～85℃,反应时间为60min,2-乙酰氧基苯甲酸的收率为88.35%。该工艺具有原料价廉易得、不腐蚀设备和无环境污染等优点,可实现清洁化生产。
A cleaner synthesis of 2-acetoxy benzoic acid by the esterification of 2-hydroxy benzoic acid and acetic anhydride using p-methylbenzenesulfonic acid as catalyst was reported. The influences of some factors on the synthesis process were studied. The optimal reaction conditions were chosen that the molar ratio of 2-hydroxy benzoic acid and acetic anhydride and p-methylbenzenesulfonic acid was 1.0 ： 2.0 ： 0. 025, reaction temperature was 80-85℃, reaction time was 60 min, etc. The yield reached 88. 35%. After adopting the new process which had many advantages, such as easy preparation, low cost, non-corrosive to equipment, and pollution-free to environment, the production of 2-acetoxy benzoic acid was carried out under cleaning.
出处
《实验技术与管理》
CAS
北大核心
2011年第11期30-31,共2页
Experimental Technology and Management
基金
辽宁省教育科学"十一五"规划立项课题高校精品课程建设的理论与实践研究(JG09DB112)
辽宁省教育厅高等学校科学研究项目计划(202092009)
