摘要
以水杨酸和乙酸酐为原料,采用尿素作催化剂合成乙酰水杨酸。考察了温度、尿素用量、n(水杨酸)∶n(乙酸酐)和时间对反应的影响。正交试验结果表明,较适宜的反应条件为:n(水杨酸)∶n(乙酸酐)=1∶3,尿素用量为水杨酸质量的5%,反应温度85℃,反应时间60 min,此条件下,乙酰水杨酸收率达94.06%。
Acetylsalicylic acid was synthesized using salicylic acid and acetic anhydride as raw materials and urea as the catalyst. Effects of reaction temperature, urea dosage, molar ratio of salicylic acid to acetic anhydride and reaction time were investigated. The results of the orthogonal test showed that acetylsalicylic acid yield of 94.06% was obtained under the optimum condition as follows： n（ salicylic acid）： n（acetic anhydride） = 1：3 ,urea dosage 5% of salicylic acid mass, reaction temperature 85 ℃, reaction time 60 min.
出处
《工业催化》
CAS
2010年第6期48-50,共3页
Industrial Catalysis
关键词
精细化学工程
尿素
催化合成
乙酰水杨酸
正交试验
fine chemical engineering
urea
catalytic synthesis
acetylsalicylic acid
orthogonal test
