摘要
目的通过口服葡萄糖耐量实验,观察血清C肽、胰岛素释放水平,计算胰岛素敏感指数,探讨肥胖对老年2型糖尿病患者几个指标的影响。方法选择本院老年2型糖尿病患者136例,根据1999年WHO糖尿病的诊断标准及患者的体重指数分为非肥胖糖尿病组60例和肥胖糖尿病组76例;另选健康检查者92例,分为非肥胖对照组40例和肥胖对照组52例。采用己糖激酶法测定血糖,采用时间分辨荧光免疫法测定C肽和胰岛素。结果非肥胖糖尿病组与非肥胖对照组,肥胖糖尿病组与肥胖对照组,肥胖对照组与非肥胖对照组,非肥胖糖尿病组与肥胖糖尿病组两两比较,各时间点C肽和胰岛素水平差异均有统计学意义(P<0.05或P<0.01)。肥胖对照组与非肥胖对照组,非肥胖糖尿病组与肥胖糖尿病组两两比较,各时间点血糖水平差异均无统计学意义(P>0.05),肥胖者服糖后血糖下降更慢。结论肥胖影响老年2型糖尿病患者的C肽和胰岛素,为该病的危险因子。
Objective To explore the effect of obesity on serum levels of C- peptide, insulin and glucose in elderly patients with diabetes. Methods 136 cases of elderly patients with diabetes were divided into non-obese diabetic group （60 cases） and obese diabetic group （76 cases） according to the 1999 WHO diagnostic criteria for diabetes and patients with a body mass index. 92 healthy controls were divided into non-obese control group （40 cases）, obesity control group （52 cases）. The blood glucose was detected by Hexokinase method. The serum levels of insulin and C-peptide were measured by chemiluminescence. Results The serum levels of insulin and C-peptide at all time point had significantly difference between patient groups and healthy control groups （P 〈 0.05）. Conclusion The Obesity could significantly affect the serum C- peptide and insulin levels in the elderly patients with type 2 diabetes. It would be a risk factor for this disease.
出处
《标记免疫分析与临床》
CAS
2014年第4期396-398,共3页
Labeled Immunoassays and Clinical Medicine
关键词
老年糖尿病
C肽
胰岛素
血糖
Elderly diabetic
C peptide
Insulin
Plasma glucose
