摘要
目的:研究血清C肽浓度及胰岛素与C肽比值的临床意义。方法:用放射免疫分析测定2型糖尿病和肾功能不全患者血清C肽、胰岛素浓度,并计算胰岛素与C肽比值。结果:肾功能不全组病人血清C肽、胰岛素水平显著高于糖尿病各组,且胰岛素与C肽比值显著低于糖尿病各组(P<0.01);在糖尿病各年龄组中,胰岛素水平无明显变化(P>0.05);但血清C肽水平随年龄增大而升高,而胰岛素与C肽比值则显著下降(P<0.01)。结论:测定血清C肽水平及胰岛素与C肽比值有助于了解糖尿病患者的肾功能状况,值得进一步深入探讨。
Objective To study the clinical meanings of changes of serum C - peptide levels and insulin/C - peptide ratio. Methods Serum insulin and C -peptide levels were determined with RIA in 171 patients with DM -2 of all ages （31 -50, n = 50, 51 -60, n =60, over 60, n =61 ） and 50 patients with renal insufficiency. The insulin/C -peptide ratio were calculated. Results The serum C - peptide and insulin levels in patients with renal insufficiency were significantly higher than those in diabetics of all age groups and the insulin/C -peptide ratio were significantly lower than those in diabetics （P 〈 0.01 ）. Among the diabetics, the serum insulin levels were about the same in the three age groups （P 〉 0. 05 ）, but the serum C - peptide levels increased as the age of patients increased with decrease of insulin/C - peptide ratio （P 〈 0.01 ）. Conclusion Abnormal changes of C - peptide levels and in sulin/C -peptide ratio in diabetics （the age -factor corrected） might reflect renal dysfunction.
出处
《放射免疫学杂志》
CAS
2006年第1期15-17,共3页
Journal of Radioimmanology
关键词
C-肽
糖尿病
胰岛索
肾功能不全
C - peptide（ C - P）, diabetes mellitus（ DM）, insulin（ INS）, renal dysfunction
