摘要
目的 对比分析糖尿病肾病和糖尿病合并的非糖尿病性肾脏疾病的不同临床特 征.探索两组疾病的临床鉴别诊断依据,建立糖尿病肾病诊断概率回归方程。方法 肾活检前临 床诊断为糖尿病肾病患者共110例,经肾活检后,按病理诊断分为两组:DN组(糖尿病肾病)60 例,NDRD组(非糖尿病性肾脏疾病)50例。对两组资料进行统计分析。结果 单因素及多因素回 归分析显示,糖尿病患病时间、收缩压、糖化血红蛋白、有无血尿和视网膜病变与糖尿病肾病诊 断相关。由所得参数建立糖尿病肾病诊断概率同归方程。经检验,方程判断糖尿病肾病灵敏度为 90％,特异度为92％,阳性预测值为93％,阴性预测值为88％,准确率为91％。结论 2型糖尿病 伴肾脏损害并不一定是糖尿病肾病,相当部分是非糖尿病性肾脏疾病,回归方程的建立可为临 床鉴别诊断提供帮助。
Objective To compare the clinical characteristics between diabetic nephropathy (DN)and diabetes with non-diabetic renal diseases (NDRD),find out the evidence for differential diagnosis and establish a diagnostic formula.Methods One hundred and ten patients were diagnosed as DN clinically.Subsequent renal biopsy showed only 60 were DN while other 50 were NDRD.Statistical analysis was performed in two groups, DN and NDRD , 60 and 50 cases respectively.Results Univariate regression analysis and stepwise multivariate regression analysis identified diabetes duration, systolic blood pressure, HbA1c concentration, presence of retinopathy, absence of hematuria as significant predictors for DN.The established diagnostic formula had a sensitivity of 90% , specificity of 92% , positive predictive value of 93% , negative predictive value of 88% , and an accuracy of 91%. Conclusions The renal injuries in diabetic subjects include DN and NDRD.The diagnostic formula may be helpful to clinical differentiation.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2005年第4期182-185,共4页
Chinese Journal of Nephrology
基金
国家自然科学基金创新研究群体科学基金(30121005)
