摘要
目的 :研究老年 型糖尿病 (DM)患者胰岛素 (INS)水平、 C肽 (CP)水平及肥胖对它们的影响。方法 : 型 DM组 :肥胖 [n =15 ,年龄 (6 8.40± 4.46 )岁 ,BMI(2 8.40± 3.2 0 ) kg/ m2 ],非肥胖 [n =19,年龄 (6 9.84± 5 .5 7)岁 ,BMI(2 0 .89± 1.88) kg/ m2 ]。对照组 :肥胖 [n =10 ,年龄 (6 8.5 0± 6 .6 0 )岁 ,BMI (2 7.93± 2 .34 ) kg/ m2 ];非肥胖 [n =13,年龄 (6 7.93± 6 .34 )岁 ,BMI(2 1.34± 2 .0 1) kg/ m2 ]。所有受试者均行 75 g葡萄糖耐量试验 (OGTT)及同步 INS释放试验及 CP释放 ,并计算胰岛素敏感指数 (ISI)。结果 :OGTT后 INS应答及 CP应答在肥胖者是相同的 ,但在非肥胖 型 DM病人空腹及糖负荷后 1,2 h INS及 CP均减少 (P<0 .0 5 )。DM组及对照组内肥胖者各时点 INS及 CP均高于非肥胖者 (P<0 .0 1) ,但肥胖者胰岛素敏感指数 (ISI)低于非肥胖者 (P <0 .0 5 )。结论 :非肥胖老年 型 DM病人主要是 INS释放受损 ,而胰岛素抵抗 (IR)轻微。肥胖老年 型 DM患者虽然 INS水平不低 ,但 IR显著。
Objective:We study the effects of insulin (INS) and c peptide (CP) level in the obese elderly patients with type Ⅱ diabetes Methods:Type Ⅱ diabetic group including obese [(n=15,age(68 40±4 46)years,BMI(28 40±3 20)kg/m 2] and non obese patients [(n=19,age(69 84±5 57)years,BMI(20 89±1 88)kg/m 2] Control group including obese [(n=10,age(68 50±6 60)years,BMI(27 93±2 34)kg/m 2]and non obese subjects [(n=13,age(67 93±6 34)years,BMI(21 34±2 01)kg/m 2] All subjects underwent 75 g oral glucose tolerance test (OGTT),insulin release test,c peptide release test,and calculated insulin sensitivity index (ISI) Results:INS and CP responses during the OGTT were similar in obese subjects of two groups The 1h,2 h levels of INS,CP after sugar load were reduced in non obese subjects of two groups (P<0 05) The levels of INS,CP of all points during INS,CP releasing tests were higher in obese subjects of two groups than that in non obese subjects (P<0 01),but ISI reduced significantly in non obese subjects compared to obese subjects Conclusion:Non obese elderly type Ⅱ diabetic patients havd a profound impairment in glucose induced insulin release but mild resistance Obese elderly type Ⅱ diabetic patients havd adequate circulating insulin level,but marked insulin resistance
出处
《广西医科大学学报》
CAS
2000年第1期14-15,共2页
Journal of Guangxi Medical University
基金
广西区自然科学基金资助课题
