摘要
脊髓损伤(SCI)后,除感觉运动功能障碍外,神经性疼痛(NP)也是严重影响患者生活质量的主要因素,其发病机理尚不清楚,目前缺乏有效治疗手段。随着影像学技术的发展,SCI后大脑结构和功能改变对NP影响的逐渐被认识,不仅有利于从宏观上揭示NP的病理机制,且为治疗提供了新的思路。本文对SCI后NP患者大脑结构和功能变化及其可能机制进行综述。
Patients with spinal cord injury(SCI)often experience neuropathic pain(NP)which seriously affects the quality of life,yet no effective treatment could be performed because of the unclear mechanisms of NP.With the development of medical imaging,it is gradually recognized that the changes of brain structure and function influence NP after SCI.These findings revealed the possible pathological mechanism of NP,thus providing new methods for the treatment of NP.The changes of brain structure and function related to NP and the possible mechanisms following SCI were reviewed in this paper.
作者
李雪静
陈楠
LI Xuejing;CHEN Nan(Department of Radiology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)
出处
《中国医学影像技术》
CSCD
北大核心
2018年第12期1889-1892,共4页
Chinese Journal of Medical Imaging Technology
基金
国家自然科学基金(81271556
81871339)
北京市自然科学基金(7113155)
北京市医院管理局临床医学发展专项经费(ZYLX201609)
关键词
脊髓损伤
神经性疼痛
脑
结构
功能
磁共振成像
Spinal cord injuries
Neuropathic pain
Brain
Structure
Function
Magnetic resonance imaging
